| Gene Symbol |
CABP1
|
| Entrez Gene |
9478
|
| Alt Symbol |
CALBRAIN, HCALB_BR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium binding protein 1
|
| Other Description |
calcium binding protein 5|calcium-binding protein 1|caldendrin
|
| Swissprots |
O95663 Q9NZU8 Q8N6H5 Q9NZU7
|
| Accessions |
EAW98209 EAW98210 EAW98211 Q9NZU7 AF169148 AAF25782 AF169149 AAF25783 AK127203 AL533429 BC015006 BC030201 AAH30201 BM716422 BQ188859 DQ895513 ABM86439 EU176343 ABW03794 NM_001033677 NP_001028849 NM_004276 NP_004267 NM_031205 NP_112482
|
| Function |
Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=S- CaBP1 is localized at or near the plasma membrane.
|
| Tissue Specificity |
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
|