CABP1
| Gene Symbol | CABP1 |
|---|---|
| Entrez Gene | 9478 |
| Alt Symbol | CALBRAIN, HCALB_BR |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium binding protein 1 |
| Other Description | calcium binding protein 5|calcium-binding protein 1|caldendrin |
| Swissprots | O95663 Q9NZU8 Q8N6H5 Q9NZU7 |
| Accessions | EAW98209 EAW98210 EAW98211 Q9NZU7 AF169148 AAF25782 AF169149 AAF25783 AK127203 AL533429 BC015006 BC030201 AAH30201 BM716422 BQ188859 DQ895513 ABM86439 EU176343 ABW03794 NM_001033677 NP_001028849 NM_004276 NP_004267 NM_031205 NP_112482 |
| Function | Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity). {ECO:0000250}. |
| Subcellular Location | Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=S- CaBP1 is localized at or near the plasma membrane. |
| Tissue Specificity | Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum. |
CaBP CRISPR/Cas9 KO Plasmid (h) - sc-409742 from Santa Cruz Biotechnology
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CaBP HDR Plasmid (h) - sc-409742-HDR from Santa Cruz Biotechnology
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CaBP Double Nickase Plasmid (h) - sc-409742-NIC from Santa Cruz Biotechnology
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CaBP Double Nickase Plasmid (h2) - sc-409742-NIC-2 from Santa Cruz Biotechnology
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CaBP CRISPR Activation Plasmid (h) - sc-409742-ACT from Santa Cruz Biotechnology
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CaBP CRISPR Activation Plasmid (h2) - sc-409742-ACT-2 from Santa Cruz Biotechnology
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CaBP Lentiviral Activation Particles (h) - sc-409742-LAC from Santa Cruz Biotechnology
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CaBP Lentiviral Activation Particles (h2) - sc-409742-LAC-2 from Santa Cruz Biotechnology
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CaBP siRNA (h) - sc-105171 from Santa Cruz Biotechnology
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CaBP shRNA Plasmid (h) - sc-105171-SH from Santa Cruz Biotechnology
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CaBP shRNA (h) Lentiviral Particles - sc-105171-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU078631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5255 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5255 from Sigma-Aldrich
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CABP1 siRNA (Human) - CRH6293 from Cohesion Biosciences
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CABP1 RNAi - H00009478-R01 from Novus Biologicals
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CABP1 - MBS8219241 from MyBioSource
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shRNA set against Human CABP1 (NM_004276.4) - SHH253161 from Creative biogene
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shRNA set against Human CABP1(NM_001033677.1) - SHG122275 from Creative biogene
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CABP1 shRNA Plasmid (Human) - CHH6293 from Cohesion Biosciences
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CABP1 miRNA 3'UTR clone - MiUTR1H-01571 from Creative biogene
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CABP1 miRNA 3'UTR clone - MiUTR3H-07789 from Creative biogene
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CABP1 miRNA 3'UTR clone - MiUTR3H-07790 from Creative biogene
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