BIN2

Gene Symbol	BIN2
Entrez Gene	51411
Alt Symbol	BRAP-1
Species	Human
Gene Type	protein-coding
Description	bridging integrator 2
Other Description	breast cancer associated protein BRAP1|breast cancer-associated protein 1|bridging integrator-2
Swissprots	Q9UBW5 Q9UKN4 Q86VV0 Q9NWK4
Accessions	BAA88125 EAW58186 EAW58187 EAW58188 Q9UBW5 AB032698 BAA88108 AF146531 AAD54227 AK000783 BAA91376 AK093638 AK225911 AK300211 BAH13239 AK314304 BAG36957 BC047686 AAH47686 BG388638 BX281612 CB996605 DB035315 XM_005268957 XP_005269014 XM_005268958 XP_005269015 XM_011538452 XP_011536754 XM_011538453 XP_011536755 NM_001290007 NP_001276936 NM_001290008 NP_001276937 NM_001290009 NP_001276938 NM_016293 NP_057377
Function	Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
Subcellular Location	Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.
Tissue Specificity	Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues. {ECO:0000269|PubMed:10903846, ECO:0000269|PubMed:23285027}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BIN2 protein fragment - ab152048 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source E. coli Species Human

BIN2 Antibody Blocking Peptide - LS-E7973 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BIN2-Antibody-N-term-Blocking-peptide - BP5779a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BIN2 Protein Lysate (APL10938) - APL10938 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human BIN2 protein - orb49226 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

BIN2 Blocking Peptide - 33R-2395 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Bridging integrator 2, BIN2, Human, Recombinant - 19-CE47 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

BIN2 fusion protein - Ag5502 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human BIN2 Protein - BP001607-CE47 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human BIN2, His-tagged - BIN2-7962H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BIN2, GST-tagged - BIN2-10231H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human BIN2, His tagged - BIN2-112H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Bridging Integrator 2 (BIN2) - RPJ554Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Human BIN2 / BRAP-1 Protein (His Tag) - 15226-H07E-100 from Sino Biological Category Protein Source E. coli Species Human

Recombinant Bridging Integrator 2 (BIN2) - RPJ554Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Bridging integrator 2(BIN2) - CSB-YP002701HU CSB-EP002701HU CSB-BP002701HU CSB-MP002701HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BIN2 / BRAP1 - TP308253 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

BIN2 / BRAP1 - TP720547 from Acris Antibodies Category Protein Prices $299.00 Sizes 10 µg Source E. coli Species Human

BIN2 Recombinant Protein Antigen - NBP2-48691PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

BIN2 Recombinant Protein Antigen - NBP2-48690PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

BIN2 Peptide, Human - M34GP01442H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Bridging Integrator 2 (BIN2) - RPU52745 from Biomatik Category Protein Prices $189.00, $387.00, $592.00, $705.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

BIN2 Recombinant Protein (OPCD01639) - OPCD01639 from Aviva Systems Biology Category Protein Source E.coli Species Human

Human BIN2 / BRAP-1 Protein (His Tag) - 15226-H07E from ABclonal Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source E. coli Species Human

Bridging Integrator 2 Recombinant Protein - 92-013 from ProSci Category Protein Prices $525.00 Sizes 50 µg Source E. coli Species Human

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