| Gene Symbol | DLG4 |
|---|---|
| Entrez Gene | 1742 |
| Alt Symbol | PSD95, SAP-90, SAP90 |
| Species | Human |
| Gene Type | protein-coding |
| Description | discs, large homolog 4 (Drosophila) |
| Other Description | Tax interaction protein 15|discs large homolog 4|disks large homolog 4|post-synaptic density protein 95|postsynaptic density protein 95|synapse-associated protein 90 |
| Swissprots | G5E939 Q92941 Q9UKK8 B7Z1S1 P78352 |
| Accessions | AAD56173 EAW90251 EAW90252 EAW90253 EAW90254 EAW90255 P78352 AA954439 AF028825 AAB84250 AK293835 BAH11607 AK296357 BAH12328 AK297346 BAH12558 AK299801 BAH13133 AK307804 AK308533 AK316096 BAH14467 BC030203 BC040533 AAH40533 BC136553 AAI36554 BC144237 U68138 AAB07736 U83192 AAC52113 XM_005256489 XP_005256546 XM_005256491 XP_005256548 XM_005256492 XP_005256549 XM_005256493 XP_005256550 XM_005256494 XP_005256551 XM_011523698 XP_011522000 XM_011523699 XP_011522001 XM_011523700 XP_011522002 XM_011523701 XP_011522003 XM_011523702 XP_011522004 XR_243545 XR_934005 NM_001128827 NP_001122299 NM_001365 NP_001356 |
| Function | Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12151521}; Peripheral membrane protein {ECO:0000269|PubMed:12151521}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269|PubMed:12151521}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Cell junction, synapse {ECO:0000269|PubMed:12151521}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. |
| Tissue Specificity | Brain. |
| Top Pathways | Huntington's disease, Glutamatergic synapse, Cocaine addiction, Hippo signaling pathway |