| Gene Symbol |
DDX11
|
| Entrez Gene |
1663
|
| Alt Symbol |
CHL1, CHLR1, KRG2, WABS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
|
| Other Description |
CHL1-like helicase homolog|CHL1-related helicase gene-1|CHL1-related protein 1|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)|DEAD/H box protein 11|KRG-2|hCHLR1|keratinocyte growth factor-regulated gene 2 protein|probable ATP-dependent RNA helicase DDX11
|
| Swissprots |
Q92998 Q92770 Q86VQ4 Q13333 Q96FC9 Q92999 Q86W62 Q92498
|
| Accessions |
AAA99060 EAW88576 EAW88577 EAW88578 EAW88579 EAW88580 EAW88581 EAW88582 EAW88583 Q96FC9 AK021703 AK297607 BAG59990 AK303139 BAG64243 BC001591 BC011264 BC012834 BC047317 BC050069 AAH50069 BC050522 AAH50522 BC111733 AAI11734 BC148224 DQ786287 U33833 AAB06962 U75967 AAB18749 U75968 AAB18750 U75969 AAB18751 X99583 CAA67895 XM_005253331 XP_005253388 XM_005253333 XP_005253390 XM_006719041 XP_006719104 XM_006719043 XP_006719106 XM_006719044 XP_006719107 XM_006719045 XP_006719108 XM_006719046 XP_006719109 XM_006719047 XP_006719110 XM_006719048 XP_006719111 XM_006719049 XP_006719112 XM_006719050 XP_006719113 XM_006719051 XP_006719114 XM_006719052 XP_006719115 XM_006719053 XP_006719116 XM_011520592 XP_011518894 XM_011520593 XP_011518895 XM_011520594 XP_011518896 XM_011520595 XP_011518897 XM_011520596 XP_011518898 XM_011520597 XP_011518899 XR_429031 XR_931278 XR_931279 XR_931280 XR_931281 NM_001257144 NP_001244073 NM_001257145 NP_001244074 NM_004399 NP_004390 NM_030653 NP_085911 NM_152438 NP_689651 NM_030655
|
| Function |
DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of t
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17105772}. Nucleus, nucleolus {ECO:0000269|PubMed:17105772}. Note=During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase). Co- localizes with bovine papillomavirus type 1 regulatory protein E2 at early stages of mitosis.
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| Tissue Specificity |
Highly expressed in spleen, B-cells, thymus, testis, ovary, small intestine, and pancreas. Very low expression seen in the brain. Expressed in dividing cells and/or cells undergoing high levels of recombination. No expression is seen in cells signaled to terminally differentiate. Expressed in keratinocyte growth factor-stimulated cells but not in serum, EGF and IL1-beta-treated keratinocytes. {ECO:0000269|PubMed:8798685, ECO:0000269|PubMed:9013641}.
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