| Gene Symbol | FGFR1 |
|---|---|
| Entrez Gene | 2260 |
| Alt Symbol | BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fibroblast growth factor receptor 1 |
| Other Description | FGFR1/PLAG1 fusion|FMS-like tyrosine kinase 2|basic fibroblast growth factor receptor 1|fms-related tyrosine kinase 2|heparin-binding growth factor receptor|hydroxyaryl-protein kinase|proto-oncogene c-Fgr |
| Swissprots | Q02063 C1KBH8 Q14307 A8K6T9 Q9UD50 P11362 Q9UDF0 Q9UDF2 Q5BJG2 Q59H40 P17049 A8K8V5 Q9UDF1 Q02065 Q14306 Q53H63 Q8N685 |
| Accessions | AAS79322 CAA01958 EAW63303 EAW63304 EAW63305 EAW63306 EAW63307 EAW63308 EAW63309 EAW63310 EAW63311 EAW63312 EAW63313 EAW63314 EAW63315 EAW63316 P11362 AB208919 BAD92156 AF173898 AAQ13645 AK001052 AK024388 AK094303 AK130555 AK222718 BAD96438 AK223126 BAD96846 AK291754 BAF84443 AK292470 BAF85159 AK309947 AW206093 BC015035 AAH15035 BC018128 AAH18128 BC091494 AAH91494 BQ774633 BX649167 CX756209 CX757985 DB300904 DQ894999 ABM85925 EF525171 EU826596 ACF47632 EU826597 ACF47633 FJ809916 ACO38645 FJ809917 ACO38646 M34185 AAA35836 M34186 AAA35837 M34187 AAA35838 M34188 AAA35839 M34641 AAA35835 M37722 AAA75007 M60485 AAA35840 M63887 AAA35958 M63888 AAA35959 M63889 AAA35960 S76658 AAD14230 X51803 CAA36101 X52833 CAA37015 X57118 CAA40400 X57119 CAA40401 X57120 CAA40402 X57121 CAA40403 X57122 CAA40404 X66945 CAA47375 Y00665 CAA68679 XM_006716303 XP_006716366 XM_006716304 XP_006716367 XM_006716305 XP_006716368 XM_006716306 XP_006716369 XM_006716307 XP_006716370 XM_006716309 XP_006716372 XM_006716310 XP_006716373 XM_006716311 XP_006716374 XM_006716312 XP_006716375 XM_006716313 XP_006716376 XM_006716314 XP_006716377 XM_011544443 XP_011542745 XM_011544444 XP_011542746 XM_011544445 XP_011542747 XM_011544446 XP_011542748 XM_011544447 XP_011542749 XM_011544448 XP_011542750 XM_011544449 XP_011542751 XM_011544450 XP_011542752 XM_011544451 XP_011542753 XM_011544452 XP_011542754 NM_001174063 NP_001167534 NM_001174064 NP_001167535 NM_001174065 NP_001167536 NM_001174066 NP_001167537 NM_001174067 NP_001167538 NM_015850 NP_056934 NM_023105 NP_075593 NM_023106 NP_075594 NM_023110 NP_075598 NM_023107 NM_023108 NM_023109 NM_023111 NM_032191 |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus. |
| Tissue Specificity | Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. {ECO:0000269|PubMed:1652059}. |
| Top Pathways | Proteoglycans in cancer, Adherens junction, Rap1 signaling pathway, Central carbon metabolism in cancer, Signaling pathways regulating pluripotency of stem cells |