INSIG1

Gene Symbol INSIG1
Entrez Gene 3638
Alt Symbol CL-6, CL6
Species Human
Gene Type protein-coding
Description insulin induced gene 1
Other Description INSIG-1 membrane protein|insulin-induced gene 1 protein
Swissprots Q53XW8 A4D2N1 A8K6L0 Q9BUV5 O15503
Accessions AAB69121 EAL23728 EAL23729 EAL23730 EAX04529 EAX04530 EAX04531 EAX04532 O15503 AA565248 AF086365 AK095977 AK291675 BAF84364 AL541939 AY112745 AAM44086 BC001880 AAH01880 BI550548 BI918342 BM995866 BQ059075 BT007227 AAP35891 DA590854 DA738378 DN996424 XM_005249542 XP_005249599 XM_005249543 XP_005249600 NM_005542 NP_005533 NM_198336 NP_938150 NM_198337 NP_938151
Function Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038}; Multi-pass membrane protein {ECO:0000269|PubMed:12202038}.
Tissue Specificity Expressed in all tissues tested with highest expression in the liver. {ECO:0000269|PubMed:12202038}.

INSIG-1 (A-9) - sc-390504 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
INSIG-1 (A-9): sc-390504. Western blot analysis of INSIG-1 expression in Hep G2 whole cell lysate.

INSIG-1 (M-15) - sc-51103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

INSIG-1 (H-70) - sc-98985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Insig1 antibody - ab70784 from Abcam

Prices $390.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Insig1 antibody (ab70784) at 0.5 µg/ml + Jurkat cell lysate

Anti-Insig1 antibody - ab112248 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Insig1 antibody (ab112248) at 1 µg/mlLane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 3 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 4 : Brain (Rat) Tissue LysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Insig1 antibody - ab86350 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Insig1 antibody (ab86350) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal lung lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Insig1 antibody - N-terminal - ab175856 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Insig1 antibody - N-terminal (ab175856) at 1/1000 dilution + Hela cell line lysate at 35 µg

Anti-INSIG1 Antibody (Internal) - LS-C70714 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (Internal, DY650) - LS-C141459 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (Internal, Biotin) - LS-C141458 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (Internal, HRP) - LS-C141461 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (Internal, DY550) - LS-C141462 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (Internal, DY488) - LS-C141460 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (N-Terminus, AP) - LS-C278343 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (N-Terminus, PE) - LS-C278346 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (N-Terminus, FITC) - LS-C278345 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (N-Terminus, APC) - LS-C278344 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (N-Terminus) - LS-C327623 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSIG1 Antibody (aa71-120) - LS-C101825 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
INSIG1 antibody LS-C101825 Western blot of Fetal Muscle lysate.

Anti-INSIG1 Antibody (C-Terminus) - LS-C101823 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
INSIG1 antibody LS-C101823 Western blot of Fetal lung lysate.

Anti-INSIG1 Antibody (C-Terminus) - LS-C110485 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
INSIG1 antibody LS-C110485 Western blot of Fetal Brain lysate.

Anti-INSIG1 Antibody - LS-C146993 from LifeSpan Bioscience

Prices $460.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of INSIG1 antibody LS-C146993.

Anti-INSIG1 Antibody (aa36-63) - LS-C165254 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
INSIG1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-INSIG1 Antibody (aa1-100) IHC-plus™ - LS-B2420 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-INSIG1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2420 concentration 5 ug/ml.

Anti-INSIG1 Antibody (aa63-112) IHC-plus™ - LS-B6815 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-INSIG1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6815 concentration 10 ug/ml.
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