INSIG1

Gene Symbol INSIG1
Entrez Gene 3638
Alt Symbol CL-6, CL6
Species Human
Gene Type protein-coding
Description insulin induced gene 1
Other Description INSIG-1 membrane protein|insulin-induced gene 1 protein
Swissprots Q53XW8 A4D2N1 A8K6L0 Q9BUV5 O15503
Accessions AAB69121 EAL23728 EAL23729 EAL23730 EAX04529 EAX04530 EAX04531 EAX04532 O15503 AA565248 AF086365 AK095977 AK291675 BAF84364 AL541939 AY112745 AAM44086 BC001880 AAH01880 BI550548 BI918342 BM995866 BQ059075 BT007227 AAP35891 DA590854 DA738378 DN996424 XM_005249542 XP_005249599 XM_005249543 XP_005249600 NM_005542 NP_005533 NM_198336 NP_938150 NM_198337 NP_938151
Function Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038}; Multi-pass membrane protein {ECO:0000269|PubMed:12202038}.
Tissue Specificity Expressed in all tissues tested with highest expression in the liver. {ECO:0000269|PubMed:12202038}.

INSIG1 293 Cell Lysate - 403513 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

INSIG1 293 Cell Lysate - 408054 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

INSIG-1 Overexpression Lysate (Native) - NBL1-12003 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: INSIG-1 Overexpression Lysate (Adult Normal) [NBL1-12003] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for INSIG-1.

INSIG1 Over-expression Lysate Product - GWB-ED1210 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

INSIG1 Over-expression Lysate Product - GWB-16E6C5 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

INSIG-1 Overexpression Lysate (Native) - NBP2-04727 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: INSIG-1 Overexpression Lysate (Adult Normal) [NBP2-04727] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for INSIG-1.

Panoply™ Human INSIG1 Knockdown Stable Cell Line - CSC-DC007672 from Creative biogene

Category Cell Line
Species Human
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