INSIG1

Gene Symbol	INSIG1
Entrez Gene	3638
Alt Symbol	CL-6, CL6
Species	Human
Gene Type	protein-coding
Description	insulin induced gene 1
Other Description	INSIG-1 membrane protein|insulin-induced gene 1 protein
Swissprots	Q53XW8 A4D2N1 A8K6L0 Q9BUV5 O15503
Accessions	AAB69121 EAL23728 EAL23729 EAL23730 EAX04529 EAX04530 EAX04531 EAX04532 O15503 AA565248 AF086365 AK095977 AK291675 BAF84364 AL541939 AY112745 AAM44086 BC001880 AAH01880 BI550548 BI918342 BM995866 BQ059075 BT007227 AAP35891 DA590854 DA738378 DN996424 XM_005249542 XP_005249599 XM_005249543 XP_005249600 NM_005542 NP_005533 NM_198336 NP_938150 NM_198337 NP_938151
Function	Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038}; Multi-pass membrane protein {ECO:0000269|PubMed:12202038}.
Tissue Specificity	Expressed in all tissues tested with highest expression in the liver. {ECO:0000269|PubMed:12202038}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Insig1 peptide - ab126817 from Abcam Category Peptide

INSIG1 Antibody Blocking Peptide - LS-E14603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

INSIG1 Antibody Blocking Peptide - LS-E14602 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

INSIG1 Antibody Blocking Peptide - LS-E14604 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

INSIG1 Antibody Blocking Peptide - LS-E14606 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

INSIG1 Antibody Blocking Peptide - LS-E9864 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

INSIG1-Antibody-N-term-Blocking-Peptide - BP8940a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

INSIG1 Blocking Peptide - 33R-10042 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

INSIG1 Blocking Peptide - 33R-9338 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

INSIG1 Blocking Peptide - 33R-4178 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

INSIG1 Blocking Peptide - 33R-9337 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

INSIG1 Blocking Peptide - 33R-10961 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

INSIG1 fusion protein - ag17420 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

INSIG1 fusion protein - Ag17418 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human INSIG1, His-tagged - INSIG1-124H from Creative Biomart Category Protein Source E.coli Species Human

KIR2DL3 - PAT-80148-1 from Nordic BioSite Category Protein Species Human

KIR2DL3 - PAT-80148-2 from Nordic BioSite Category Protein Species Human

Insig1 Blocking Peptide - 3854BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

INSIG1 Peptide, Human - M34GP07672H from Creative Peptides Category Peptide Source Synthetic. Species Human

Insulin-induced gene 1 protein (INSIG1), Recombinant Protein - MBS7017496 from MyBioSource Category Protein Prices $1,090.00, $2,075.00, $3,285.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Insulin-induced gene 1 protein (INSIG1), Recombinant Protein - MBS1074329 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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