INSIG1

Gene Symbol INSIG1
Entrez Gene 3638
Alt Symbol CL-6, CL6
Species Human
Gene Type protein-coding
Description insulin induced gene 1
Other Description INSIG-1 membrane protein|insulin-induced gene 1 protein
Swissprots Q53XW8 A4D2N1 A8K6L0 Q9BUV5 O15503
Accessions AAB69121 EAL23728 EAL23729 EAL23730 EAX04529 EAX04530 EAX04531 EAX04532 O15503 AA565248 AF086365 AK095977 AK291675 BAF84364 AL541939 AY112745 AAM44086 BC001880 AAH01880 BI550548 BI918342 BM995866 BQ059075 BT007227 AAP35891 DA590854 DA738378 DN996424 XM_005249542 XP_005249599 XM_005249543 XP_005249600 NM_005542 NP_005533 NM_198336 NP_938150 NM_198337 NP_938151
Function Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038}; Multi-pass membrane protein {ECO:0000269|PubMed:12202038}.
Tissue Specificity Expressed in all tissues tested with highest expression in the liver. {ECO:0000269|PubMed:12202038}.

INSIG-1 CRISPR/Cas9 KO Plasmid (h) - sc-401381 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-1 HDR Plasmid (h) - sc-401381-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-1 Double Nickase Plasmid (h) - sc-401381-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-1 Double Nickase Plasmid (h2) - sc-401381-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-1 CRISPR Activation Plasmid (h) - sc-401381-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-1 CRISPR Activation Plasmid (h2) - sc-401381-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-1 Lentiviral Activation Particles (h) - sc-401381-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-1 Lentiviral Activation Particles (h2) - sc-401381-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-1 siRNA (h) - sc-44432 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INSIG-1 shRNA Plasmid (h) - sc-44432-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INSIG-1 shRNA (h) Lentiviral Particles - sc-44432-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU086971 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10699 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10699 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10985 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10985

INSIG1 siRNA (Human) - CRH2439 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

INSIG1 - MBS8219080 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human INSIG1 (NM_005542.4) - SHH319821 from Creative biogene

Category siRNA
Species Reactivities Human

Human INSIG1 siRNA - orb262941 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

INSIG1 shRNA Plasmid (Human) - CHH2439 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

INSIG1 miRNA 3'UTR clone - MiUTR3H-04633 from Creative biogene

Species Reactivities Human

INSIG1 miRNA 3'UTR clone - MiUTR3H-04634 from Creative biogene

Species Reactivities Human
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