| Gene Symbol | IFITM3 |
|---|---|
| Entrez Gene | 10410 |
| Alt Symbol | 1-8U, DSPA2b, IP15 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon induced transmembrane protein 3 |
| Other Description | dispanin subfamily A member 2b|interferon-induced transmembrane protein 3|interferon-inducible protein 1-8U |
| Swissprots | Q01628 Q96J15 Q96HK8 Q53Y76 |
| Accessions | AFF60304 AFF60305 AFF60306 AFF60307 AFF60308 AFF60309 AFF60310 AFF60311 AFF60312 AFF60313 AFF60314 AFF60315 AFF60316 AFF60317 AFF60318 AFF60319 AFF60320 AFF60321 AFF60322 AFF60323 AFF60324 AFF60325 AFF60326 AFF60327 AFF60328 AFF60329 AFF60330 AFF60331 AFF60332 AFF60333 AFF60334 AFF60335 AFF60336 AFF60337 AFF60338 AFF60339 AFF60340 AFF60341 AFF60342 AFF60343 AFF60344 AFF60345 AFF60346 AFF60347 AFF60348 AFF60349 AFF60350 AFF60351 AFF60352 AFF60353 AFF60354 AFF60355 EAW50866 Q01628 AI355192 AK292173 BAF84862 AM392723 CAL37601 AM393694 CAL38570 BC006794 AAH06794 BC008417 AAH08417 BC022439 AAH22439 BC070243 AAH70243 BQ937265 BT006892 AAP35538 DB261103 DQ891098 ABM82024 DQ894280 ABM85206 X57352 CAA40626 NM_021034 NP_066362 NR_049759 |
| Function | IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localizatio |
| Subcellular Location | Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. |