RC3H2

Gene Symbol RC3H2
Entrez Gene 54542
Alt Symbol MNAB, RNF164
Species Human
Gene Type protein-coding
Description ring finger and CCCH-type domains 2
Other Description RING finger protein 164|membrane associated DNA binding protein|membrane-associated nucleic acid binding protein|membrane-associated nucleic acid-binding protein|ring finger and CCCH-type zinc finger domain-containing protein 2|ring finger and CCCH-type zinc finger domains 2|roquin-2
Swissprots Q9HBD2 Q86ST6 Q9HBD1 Q5JPD7 Q9NWN9 Q9H5J2 Q4VXB1 Q8N3D6 Q96F27 Q9NXE1
Accessions CAD26769 EAW87547 EAW87548 EAW87549 EAW87550 EAW87551 Q9HBD1 AF255303 AAG00432 AF255304 AAG00433 AK000308 BAA91073 AK000720 BAA91340 AK027042 BAB15634 AK123569 AK125196 AK226010 AL833177 CAI46182 AL833455 AL834431 CAD39091 AW291376 BC011688 AAH11688 BC044642 AAH44642 BU783286 NM_001100588 NP_001094058 NM_018835 NP_061323
Function Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS- stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, P-body {ECO:0000250}. Note=During stress, such as that induced by arsenite, localizes to cytosolic stress granules. Localization to stress granules, but not to P- bodies, depends upon the RING-type zinc finger. {ECO:0000269|PubMed:20412057}.
Tissue Specificity Expressed in spleen, testis, ovary and small intestine. {ECO:0000269|PubMed:10938276}.

MNAB (E-20) - sc-165026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MNAB (E-20): sc-165026. Western blot analysis of MNAB expression in K-562 (A) and Raji (B) whole cell lysates.

MNAB (P-17) - sc-165028 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RC3H2 antibody - ab99090 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RC3H2 antibody (ab99090) at 1 µg/ml + PANC1 cell lysate at 10 µg

Anti-RC3H2 antibody - ab194421 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-RC3H2 antibody (ab194421) at 1/1000 dilution + recombinant RC3H2 protein fragment at 0.2 µgdeveloped using the ECL technique

Anti-RC3H2 Antibody (aa395-444) - LS-C110772 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RC3H2 antibody LS-C110772 Western blot of PANC1 cell lysate.

MNAB Antibody - NBP1-55060 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MNAB Antibody [NBP1-55060] - Human Fetal Heart, Antibody Dilution: 1.0 ug/ml.

MNAB Antibody - NBP2-13212 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MNAB Antibody [NBP2-13212] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp<br/>Lane 4: Human plasma (IgG/HSA depleted)

MNAB Antibody - H00054542-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: MNAB Antibody [H00054542-A01] - MNAB polyclonal antibody (A01), Lot # 051109JC01 Western Blot analysis of MNAB expression in A-431 ( Cat # L015V1 ).

Anti-RC3H2 antibody produced in rabbit - HPA042863 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RC3H2:<B>Cat. No. HPA042863</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in renal tubules.

Anti-RC3H2 antibody produced in rabbit - SAB2105506 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RC3H2: <B>Cat. No. SAB2105506</B>: RC3H2 in PANC1 cell lysates with RC3H2 antibody at 1.0 μg/mL.

RC3H2 antibody - middle region (ARP43260_P050) - ARP43260_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RC3H2 antibody - 70R-2802 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

RC3H2 / RNF164 antibody - H00054542-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
MNAB polyclonal antibody (A01), Lot # 051109JC01 Western Blot analysis of MNAB expression in A-431 ( Cat # L015V1 ).

RC3H2 Antibody - GWB-MP420F from Genway Biotech

Prices $404.00
Sizes 50 µg
Clonality Polyclonal

Anti-RC3H2 (aa 748-847) polyclonal antibody - DPAB-DC2336 from Creative Diagnostics

Host Mouse
Clonality Polyclonal

RC3H2 antibody, Internal - GTX46912 from GeneTex

Prices $299.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-RC3H2 antibody, Internal used in Western blot. GTX46912

RC3H2, Polyclonal Antibody - MBS5300084 from MyBioSource

Prices $455.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

RC3H2 Antibody - abx122945 from Abbexa

Host Rabbit
Clonality Polyclonal

RC3H2 Antibody,Biotin conjugated - CSB-PA884510LD01HU from Cusabio

Host Rabbit
Clonality Polyclonal

RC3H2 Antibody,FITC conjugated - CSB-PA884510LC01HU from Cusabio

Host Rabbit
Clonality Polyclonal

RC3H2 Antibody,HRP conjugated - CSB-PA884510LB01HU from Cusabio

Host Rabbit
Clonality Polyclonal

RC3H2 Antibody - CSB-PA884510LA01HU from Cusabio

Host Rabbit
Clonality Polyclonal

RC3H2 / RNF164 antibody - TA329879 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WB Suggested Anti-RC3H2 Antibody Titration: 0.2-1 ug/ml; Positive Control: PANC1 cell lysate

RC3H2/MNAB Antibody - A305-149A from Bethyl Labs

Prices $99.00, $339.00
Sizes 10 µl (1 mg/ml), 100 µl (1 mg/ml)
Host Rabbit
Clonality Polyclonal

RC3H2/MNAB Antibody - A305-150A from Bethyl Labs

Prices $99.00, $339.00
Sizes 10 µl (1 mg/ml), 100 µl (1 mg/ml)
Host Rabbit
Clonality Polyclonal
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