| Gene Symbol |
RC3H2
|
| Entrez Gene |
54542
|
| Alt Symbol |
MNAB, RNF164
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger and CCCH-type domains 2
|
| Other Description |
RING finger protein 164|membrane associated DNA binding protein|membrane-associated nucleic acid binding protein|membrane-associated nucleic acid-binding protein|ring finger and CCCH-type zinc finger domain-containing protein 2|ring finger and CCCH-type zinc finger domains 2|roquin-2
|
| Swissprots |
Q9HBD2 Q86ST6 Q9HBD1 Q5JPD7 Q9NWN9 Q9H5J2 Q4VXB1 Q8N3D6 Q96F27 Q9NXE1
|
| Accessions |
CAD26769 EAW87547 EAW87548 EAW87549 EAW87550 EAW87551 Q9HBD1 AF255303 AAG00432 AF255304 AAG00433 AK000308 BAA91073 AK000720 BAA91340 AK027042 BAB15634 AK123569 AK125196 AK226010 AL833177 CAI46182 AL833455 AL834431 CAD39091 AW291376 BC011688 AAH11688 BC044642 AAH44642 BU783286 NM_001100588 NP_001094058 NM_018835 NP_061323
|
| Function |
Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS- stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, P-body {ECO:0000250}. Note=During stress, such as that induced by arsenite, localizes to cytosolic stress granules. Localization to stress granules, but not to P- bodies, depends upon the RING-type zinc finger. {ECO:0000269|PubMed:20412057}.
|
| Tissue Specificity |
Expressed in spleen, testis, ovary and small intestine. {ECO:0000269|PubMed:10938276}.
|