BRD7

Gene Symbol	BRD7
Entrez Gene	29117
Alt Symbol	BP75, CELTIX1, NAG4
Species	Human
Gene Type	protein-coding
Description	bromodomain containing 7
Other Description	75 kDa bromodomain protein|bromodomain-containing protein 7|protein CELTIX-1
Swissprots	Q9BV48 Q8N2L9 Q96KA4 Q4VC09 Q9UH59 Q9NPI1
Accessions	EAW82756 EAW82757 EAW82758 EAW82759 Q9NPI1 AF152604 AAF75126 AF213969 AAF19526 AJ271881 CAB72445 AK027308 BAB55031 AK074613 BAC11089 AW615116 BC001611 AAH01611 BC050728 AAH50728 BC094706 AAH94706 CD677718 DA645362 XM_011523046 XP_011521348 XM_011523047 XP_011521349 XM_011523048 XP_011521350 XM_011523049 XP_011521351 XM_011523050 XP_011521352 XR_933289 XR_933290 XR_933291 NM_001173984 NP_001167455 NM_013263 NP_037395
Function	Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMe
Subcellular Location	Isoform 2: Nucleus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BRD7 293T Cell Transient Overexpression Lysate(Denatured) - H00029117-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

BRD7 overexpression lysate - LY415698 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

BRD7 overexpression lysate - LY433395 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

BRD7 293 Cell Lysate - 407384 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

BRD7 Overexpression Lysate (Native) - NBL1-08024 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

BRD7 (h): 293T Lysate - sc-116362 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

BRD7 Over-expression Lysate Product - GWB-BCBEBC from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

BRD7 Overexpression Lysate (Denatured) - H00029117-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human BRD7 Knockdown Stable Cell Line - CSC-DC001529 from Creative biogene Category Cell Line Species Human

Human BRD7 Knockout Cell Line-HeLa - CSC-RT0742 from Creative biogene Category Cell Line Species Human

BRD7 KO Cell Lysate-HeLa - CLKO-0246 from Creative biogene Category Cell Lysate

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