SMC2

Gene Symbol SMC2
Entrez Gene 850589
Alt Symbol -
Species Yeast
Gene Type protein-coding
Description condensin subunit SMC2
Other Description -
Swissprots P38989 D6VTR1
Accessions DAA12471 P38989 NM_001179996 NP_116687
Function Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular Location Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Top Pathways Cell cycle - yeast