Gene Symbol | SLC22A12 |
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Entrez Gene | 116085 |
Alt Symbol | OAT4L, RST, URAT1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 22 (organic anion/urate transporter), member 12 |
Other Description | organic anion transporter 4-like protein|renal-specific transporter|solute carrier family 22 (organic anion/cation transporter), member 12|solute carrier family 22 member 12|urate anion exchanger 1|urate transporter 1 |
Swissprots | Q19PF8 Q19PF7 G3XAN7 Q96DT2 Q96S37 Q19PF9 B7WPG1 Q19PG0 Q6UXW3 |
Accessions | AAK68156 ABF74569 ABF74570 ABF74571 ABF74572 ABF74573 CAC51145 EAW74271 EAW74272 EAW74273 EAW74274 EAW74275 EAW74276 Q96S37 AB050269 BAB68364 AB071863 BAB96750 AK055737 BAG51565 AK122599 BAG53617 AK309588 AK315061 AY358183 AAQ88550 BC026291 AAH26291 BC053348 AAH53348 BX104022 DA631511 DQ655911 DQ655912 XM_006718430 XP_006718493 XM_006718431 XP_006718494 NM_001276326 NP_001263255 NM_001276327 NP_001263256 NM_144585 NP_653186 NM_153378 NP_700357 |
Function | Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. {ECO:0000269|PubMed:12024214}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:12024214}; Multi-pass membrane protein {ECO:0000269|PubMed:12024214}. Note=Detected in the luminal membrane of the epithelium of renal proximal tubules. |
Tissue Specificity | Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex. {ECO:0000269|PubMed:12024214, ECO:0000269|PubMed:15304510}. |
SLC22A12 CRISPR/Cas9 KO Plasmid (h) - sc-406110 from Santa Cruz Biotechnology
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SLC22A12 HDR Plasmid (h) - sc-406110-HDR from Santa Cruz Biotechnology
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SLC22A12 Double Nickase Plasmid (h) - sc-406110-NIC from Santa Cruz Biotechnology
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SLC22A12 Double Nickase Plasmid (h2) - sc-406110-NIC-2 from Santa Cruz Biotechnology
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SLC22A12 CRISPR Activation Plasmid (h) - sc-406110-ACT from Santa Cruz Biotechnology
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SLC22A12 CRISPR Activation Plasmid (h2) - sc-406110-ACT-2 from Santa Cruz Biotechnology
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SLC22A12 Lentiviral Activation Particles (h) - sc-406110-LAC from Santa Cruz Biotechnology
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SLC22A12 Lentiviral Activation Particles (h2) - sc-406110-LAC-2 from Santa Cruz Biotechnology
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SLC22A12 siRNA (h) - sc-96373 from Santa Cruz Biotechnology
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SLC22A12 shRNA Plasmid (h) - sc-96373-SH from Santa Cruz Biotechnology
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SLC22A12 shRNA (h) Lentiviral Particles - sc-96373-V from Santa Cruz Biotechnology
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SLC22A12 RNAi - H00116085-R02 from Novus Biologicals
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SLC22A12 RNAi - H00116085-R01 from Novus Biologicals
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MISSION® esiRNA - EHU158401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2537 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2537 from Sigma-Aldrich
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SLC22A12 siRNA (Human) - CRJ4483 from Cohesion Biosciences
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SLC22A12 - MBS8203712 from MyBioSource
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shRNA set against Human SLC22A12 (NM_144585.2) - SHH409028 from Creative biogene
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shRNA set against Human SLC22A12(NM_144585.2) - SHL001060 from Creative biogene
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Human SLC22A12 siRNA - orb274984 from Biorbyt
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SLC22A12 shRNA Plasmid (Human) - CHJ4483 from Cohesion Biosciences
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SLC22A12 miRNA 3'UTR clone - MiUTR1H-09458 from Creative biogene
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