TPM1

Gene Symbol TPM1
Entrez Gene 7168
Alt Symbol C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA
Species Human
Gene Type protein-coding
Description tropomyosin 1 (alpha)
Other Description alpha-tropomyosin|cardiomyopathy, hypertrophic 3|sarcomeric tropomyosin kappa|tropomyosin alpha-1 chain
Swissprots Q7Z6L8 Q6DV89 Q9UCI2 Q6DV90 Q86W64 B7Z5T7 Q9UCY9 P09493 Q96IK2 D9YZV2 D9YZV3 P09494 Q9Y427 Q9UCI1 P10469 D9YZV8
Accessions ADL14500 ADL14501 ADL14502 ADL14503 ADL14504 ADL14505 ADL14506 EAW77619 EAW77620 EAW77621 EAW77622 EAW77623 EAW77624 EAW77625 EAW77626 EAW77627 EAW77628 EAW77629 EAW77630 EAW77631 EAW77632 EAW77633 EAW77634 EAW77635 P09493 AB209041 BAD92278 AF474156 AAL84569 AJ000147 CAA03930 AJ001055 CAA04505 AK055197 AK057989 AK092051 AK092573 AK129882 BAC85248 AK131384 BAD18535 AK298625 BAH12832 AK299387 BAH13023 AK301319 BAH13458 AK309170 AL050179 CAB43309 AY640414 AAT68294 AY640415 AAT68295 BC007433 AAH07433 BC050473 AAH50473 BC053545 AAH53545 BG107949 BX458841 CD679271 CN423297 CN423344 DQ424903 ABD83668 DQ893259 ABM84185 DQ896588 ABM87587 EU832801 ACE87812 GQ129381 ACT64515 L02922 AAA16888 L02923 AAA16889 M19713 AAA61225 M19714 AAA61226 M19715 AAA61227 X12369 CAA30930 Z24727 CAA80853 XM_005254637 XP_005254694 XM_005254638 XP_005254695 XM_005254639 XP_005254696 XM_005254640 XP_005254697 XM_005254641 XP_005254698 XM_005254645 XP_005254702 XM_005254646 XP_005254703 XM_005254647 XP_005254704 XM_005254648 XP_005254705 XM_005254650 XP_005254707 XM_005254651 XP_005254708 XM_005254652 XP_005254709 XM_005254653 XP_005254710 XM_006720667 XP_006720730 XM_006720669 XP_006720732 NM_000366 NP_000357 NM_001018004 NP_001018004 NM_001018005 NP_001018005 NM_001018006 NP_001018006 NM_001018007 NP_001018007 NM_001018008 NP_001018008 NM_001018020 NP_001018020 NM_001301244 NP_001288173 NM_001301289 NP_001288218
Function Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Subcellular Location Cytoplasm, cytoskeleton.
Tissue Specificity Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle. {ECO:0000269|PubMed:15249230, ECO:0000269|Ref.15}.
Top Pathways Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes

Tropomyosin-1/3 (D17B8) Rabbit mAb - 3913 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D17B8
Western blot analysis of extracts from human, mouse and rat heart tissue and C2C12 cells using Tropomyosin-1/3 (D17B8) Rabbit mAb.

Tropomyosin-1 (D12H4) Rabbit mAb - 3910 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D12H4
Western blot analysis of extracts from human, mouse and rat heart tissue and C2C12 cells using Tropomyosin-1 (D12H4) Rabbit mAb.

Tropomyosin (C-3) - sc-376339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tropomyosin (C-3): sc-376339. Western blot analysis of Tropomyosin expression in non-transfected 293T: sc-117752 (A), human Tropomyosin transfected 293T: sc-113364 (B) and Sol8 (C) whole cell lysates.

Tropomyosin (CH1) - sc-58868 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tropomyosin (CH1): sc-58868. Western blot analysis of Tropomyosin expression in L8 (A) whole cell lysate, rat skeletal muscle (B), and human heart (C,D) tissue extract, under reducing (A,B,C) and non-reducing (D) conditions.

Tropomyosin (D-17) - sc-21806 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tropomyosin (D-17): sc-21806. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic and intercalated disc staining of myocytes.

Tropomyosin (E-16) - sc-21807 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tropomyosin (E-16): sc-21807. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

Tropomyosin (E-17) - sc-18174 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tropomyosin (E-17): sc-18174. Western blot analysis of Tropomyosin expression in C2C12 (A), Sol8 (B) and CCD-1064Sk (C) whole cell lysates.

Tropomyosin (SPM224) - sc-56603 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tropomyosin (SPM224): sc-56603. Western blot analysis of Tropomyosin expression in Sol8 whole cell lysate.

Tropomyosin (FL-284) - sc-28543 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Tropomyosin (FL-284): sc-28543. Western blot analysis of Tropomyosin expression in HeLa (A) and MIA PaCa-2 (B) whole cell lysates.

Tropomyosin (F-6) - sc-74480 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tropomyosin (F-6): sc-74480. Western blot analysis of Tropomyosin expression in CCD-1064Sk (A) and Sol8 (B) whole cell lysates, rat skeletal muscle tissue extract (C) and porcine recombinant Tropomyosin (D).

Tropomyosin α (F-6) - sc-376541 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tropomyosin α (F-6): sc-376541. Western blot analysis of Tropomyosin α expression in non-transfected: sc-117752 (A) and human Tropomyosin α transfected: sc-159958 (B) 293T whole cell lysates.

Tropomyosin α (V-21) - sc-32516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tropomyosin (V-21): sc-32516. Western blot analysis of Tropomyosin expression in Sol8 whole cell lysate.

Tropomyosin α (K-21) - sc-32514 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tropomyosin α (K-21): sc-32514. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

Anti-Tropomyosin 1 (alpha) antibody - ab97587 from Abcam

Host Sheep
Clonality Polyclonal

Anti-Tropomyosin 1 (alpha) antibody - ab135876 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Tropomyosin 1 (alpha) antibody (ab135876) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-Tropomyosin 1 (alpha) antibody [CH1] - ab150763 from Abcam

Prices $376.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone CH1
Immunohistochemical analysis of formalin fixed, paraffin embedded Human heart muscle tissue labeling Tropomyosin 1 (alpha) with ab150763 at 2 µg/ml for 30 minutes at room temperature.

Anti-Tropomyosin 1 (alpha) antibody [EPR5158] - ab109505 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5158
All lanes : Anti-Tropomyosin 1 (alpha) antibody [EPR5158] (ab109505) at 1/1000 dilutionLane 1 : Human heart lysateLane 2 : Human skeletal muscle lysateLane 3 : HT-1080 cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Tropomyosin 1 (alpha) antibody [EPR5159] - ab133292 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5159
Imunohistochemical analysis of paraffin-embedded Human muscle tissue labelling Tropomyosin 1 (alpha) with ab133292 at 1/100 dilution.

Anti-Tropomyosin antibody - ab97903 from Abcam

Host Sheep
Clonality Polyclonal

Anti-Tropomyosin antibody - ab76640 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-Tropomyosin antibody (ab76640) at 5 µg/ml + immunogen at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-Tropomyosin antibody - ab77884 from Abcam

Prices $359.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-TPM1 / Tropomyosin Antibody - LS-C192410 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of TPM1 pAb in extracts from HT-1080 cells and mouse heart tissue.

Anti-TPM1 / Tropomyosin Antibody (aa40-89) - LS-C200034 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Tropomyosin alpha antibody in extracts from HeLa cells.

Anti-TPM1 / Tropomyosin Antibody (C-Terminus, clone EPR5159) - LS-C138302 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5159
IHC of paraffin-embedded human muscle tissue using anti-Tropomyosin-1/3 antibody.

Anti-TPM1 / Tropomyosin Antibody IHC-plus™ - LS-B4800 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Tropomyosin 1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4800 concentration 10 ug/ml.
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