TPM1

Gene Symbol	TPM1
Entrez Gene	7168
Alt Symbol	C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA
Species	Human
Gene Type	protein-coding
Description	tropomyosin 1 (alpha)
Other Description	alpha-tropomyosin|cardiomyopathy, hypertrophic 3|sarcomeric tropomyosin kappa|tropomyosin alpha-1 chain
Swissprots	Q7Z6L8 Q6DV89 Q9UCI2 Q6DV90 Q86W64 B7Z5T7 Q9UCY9 P09493 Q96IK2 D9YZV2 D9YZV3 P09494 Q9Y427 Q9UCI1 P10469 D9YZV8
Accessions	ADL14500 ADL14501 ADL14502 ADL14503 ADL14504 ADL14505 ADL14506 EAW77619 EAW77620 EAW77621 EAW77622 EAW77623 EAW77624 EAW77625 EAW77626 EAW77627 EAW77628 EAW77629 EAW77630 EAW77631 EAW77632 EAW77633 EAW77634 EAW77635 P09493 AB209041 BAD92278 AF474156 AAL84569 AJ000147 CAA03930 AJ001055 CAA04505 AK055197 AK057989 AK092051 AK092573 AK129882 BAC85248 AK131384 BAD18535 AK298625 BAH12832 AK299387 BAH13023 AK301319 BAH13458 AK309170 AL050179 CAB43309 AY640414 AAT68294 AY640415 AAT68295 BC007433 AAH07433 BC050473 AAH50473 BC053545 AAH53545 BG107949 BX458841 CD679271 CN423297 CN423344 DQ424903 ABD83668 DQ893259 ABM84185 DQ896588 ABM87587 EU832801 ACE87812 GQ129381 ACT64515 L02922 AAA16888 L02923 AAA16889 M19713 AAA61225 M19714 AAA61226 M19715 AAA61227 X12369 CAA30930 Z24727 CAA80853 XM_005254637 XP_005254694 XM_005254638 XP_005254695 XM_005254639 XP_005254696 XM_005254640 XP_005254697 XM_005254641 XP_005254698 XM_005254645 XP_005254702 XM_005254646 XP_005254703 XM_005254647 XP_005254704 XM_005254648 XP_005254705 XM_005254650 XP_005254707 XM_005254651 XP_005254708 XM_005254652 XP_005254709 XM_005254653 XP_005254710 XM_006720667 XP_006720730 XM_006720669 XP_006720732 NM_000366 NP_000357 NM_001018004 NP_001018004 NM_001018005 NP_001018005 NM_001018006 NP_001018006 NM_001018007 NP_001018007 NM_001018008 NP_001018008 NM_001018020 NP_001018020 NM_001301244 NP_001288173 NM_001301289 NP_001288218
Function	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle. {ECO:0000269|PubMed:15249230, ECO:0000269|Ref.15}.
Top Pathways	Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Tropomyosin 1 (alpha) full length protein - ab166876 from Abcam Category Protein Source E. coli Species Human

Human Tropomyosin 1 (alpha) full length protein - ab99214 from Abcam Category Protein Source E. coli Species Human

Human Tropomyosin full length protein - ab119162 from Abcam Category Protein Source E. coli Species Human

TPM1 / Tropomyosin Antibody Blocking Peptide - LS-E15250 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Tropomyosin-1 Partial Recombinant Protein - H00007168-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Tropomyosin-1 Recombinant Protein - H00007168-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Tropomyosin-1 Protein - NBP1-48329 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

TPM1 Protein (OPPA01371) - OPPA01371 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human Tropomyosin protein - orb81425 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human TPM1 protein (His Tag) - orb139795 from Biorbyt Category Protein Prices $357.00, $527.00 Sizes 50 μg, 100 μg Source E. coli Species Human

TPM1 protein (His tag) - 80R-1445 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Tropomyosin-1 (TPM1) (1-284, His-tag) - AR09621PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Tropomyosin-1 (TPM1) (1-284, His-tag) - AR09621PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Tropomyosin-1 (TPM1) - H00007168-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Tropomyosin-1 (TPM1) - H00007168-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Tropomyosin-1 (TPM1) - H00007168-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Tropomyosin-1 (TPM1) - H00007168-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TPM1, 1-284aa, Human, His tag, E.coli - 01-1919-1 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Tropomyosin alpha -1 Chain, TPM1, Human, Recombinant - 19-C261 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

TPM1 Human - PRPS-476 from NeoScientific Category Protein Prices $65.00, $169.00, $6,240.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human TPM1 Protein - BP001087-C261 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human TPM1 Protein - BP001087-PRO-469 from Syd Labs Category Protein Prices $160.00, $4,800.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

TPM1, 1-284aa, Recombinant Protein - GWB-P1355C from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

TPM1 Human Protein - GWB-BSP695 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,225.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human Tropomyosin 1 (Alpha), His-tagged - TPM1-2789H from Creative Biomart Category Protein Source E.coli.

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