ASNA1

Gene Symbol	ASNA1
Entrez Gene	439
Alt Symbol	ARSA-I, ARSA1, ASNA-I, GET3, TRC40, hASNA-I
Species	Human
Gene Type	protein-coding
Description	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Other Description	ATPase ASNA1|golgi to ER traffic 3 homolog|transmembrane domain recognition complex 40 kDa ATPase subunit|transmembrane domain recognition complex, 40kDa
Swissprots	O43681 A6NHP8 Q53FC6 A8K740 Q92849
Accessions	AAP45050 EAW84303 O43681 AF047469 AAC03551 AK223363 BAD97083 AK291855 BAF84544 AK293588 BAG57056 BC002651 AAH02651 BG426136 JF432148 ADZ15365 U60276 AAC50731 NM_004317 NP_004308
Function	ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling. {ECO:0000255|HAMAP-Rule:MF_03112, ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:18477612}.
Subcellular Location	Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
Tissue Specificity	Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle. {ECO:0000269|PubMed:9774623}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ASNA1-Over-expression-Lysate - LY10300a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ASNA1 293T Cell Transient Overexpression Lysate(Denatured) - H00000439-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ASNA1 overexpression lysate - LY418062 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ASNA1 Overexpression Lysate (Denatured) - H00000439-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

ASNA1 Overexpression Lysate (Native) - NBP2-07880 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human ASNA1 Knockdown Stable Cell Line - CSC-DC001049 from Creative biogene Category Cell Line Species Human

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