ASNA1

Gene Symbol	ASNA1
Entrez Gene	439
Alt Symbol	ARSA-I, ARSA1, ASNA-I, GET3, TRC40, hASNA-I
Species	Human
Gene Type	protein-coding
Description	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Other Description	ATPase ASNA1|golgi to ER traffic 3 homolog|transmembrane domain recognition complex 40 kDa ATPase subunit|transmembrane domain recognition complex, 40kDa
Swissprots	O43681 A6NHP8 Q53FC6 A8K740 Q92849
Accessions	AAP45050 EAW84303 O43681 AF047469 AAC03551 AK223363 BAD97083 AK291855 BAF84544 AK293588 BAG57056 BC002651 AAH02651 BG426136 JF432148 ADZ15365 U60276 AAC50731 NM_004317 NP_004308
Function	ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling. {ECO:0000255|HAMAP-Rule:MF_03112, ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:18477612}.
Subcellular Location	Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
Tissue Specificity	Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle. {ECO:0000269|PubMed:9774623}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ARSA CRISPR/Cas9 KO Plasmid (h) - sc-404921 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ARSA HDR Plasmid (h) - sc-404921-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARSA Double Nickase Plasmid (h) - sc-404921-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARSA Double Nickase Plasmid (h2) - sc-404921-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARSA CRISPR Activation Plasmid (h) - sc-404921-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ARSA CRISPR Activation Plasmid (h2) - sc-404921-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ARSA Lentiviral Activation Particles (h) - sc-404921-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARSA Lentiviral Activation Particles (h2) - sc-404921-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARSA siRNA (h) - sc-105093 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ARSA shRNA Plasmid (h) - sc-105093-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ARSA shRNA (h) Lentiviral Particles - sc-105093-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ASNA1 RNAi - H00000439-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU068651 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3600 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3600 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00669 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00669

ASNA1 siRNA (Human) - CRH0316 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ASNA1 RNAi - H00000439-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ASNA1 - MBS8210597 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ASNA1 (NM_004317.2) - SHH241538 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ASNA1(NM_004317.2) - SHG074631 from Creative biogene Category siRNA Species Reactivities Human

Human ASNA1 siRNA - orb260818 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ASNA1 shRNA Plasmid (Human) - CHH0316 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ASNA1 miRNA 3'UTR clone - MiUTR1H-00640 from Creative biogene Species Reactivities Human

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