| Gene Symbol | rad50 |
|---|---|
| Entrez Gene | 37564 |
| Alt Symbol | 6339, CG6339, Dmel\CG6339, Dmrad50, RAD50, Rad50 |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | CG6339 gene product from transcript CG6339-RE |
| Other Description | CG6339-PD|CG6339-PE|rad50-PD|rad50-PE |
| Swissprots | B6UXV2 B6UXU3 B6UXT6 B6UXT7 B6UXS6 B6UXU9 B6UXU4 B6UXT3 B6UXT9 B6UXT4 B6UXU1 Q9W252 Q960E0 B6UXU2 B6UXU7 B6UXU6 B6UXT1 B6UXV1 Q86NZ9 B6UXV0 B6UXT8 B6UXT2 B6UXU8 B6UXU5 B6UXT5 |
| Accessions | AAF46847 AFH08214 Q9W252 NM_001259532 NP_001246461 NM_166533 NP_726199 |
| Function | Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair. The complex participates in processes such as DNA recombination, DNA repair, genome stability, telomere integrity and meiosis. The MRN complex may protect telomeres by facilitating recruitment of HOAP and HP1 at chromosome ends. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity. {ECO:0000269|PubMed:15135728, ECO:0000269|PubMed:15296753}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15296753}. Chromosome {ECO:0000269|PubMed:15296753}. Chromosome, telomere {ECO:0000269|PubMed:15296753}. Note=Uniformly distributed along mitotic chromosomes. |
| Top Pathways | Homologous recombination, Non-homologous end-joining |