| Gene Symbol | RPO21 |
|---|---|
| Entrez Gene | 851415 |
| Alt Symbol | RPB1, RPB220, SUA8 |
| Species | Yeast |
| Gene Type | protein-coding |
| Description | DNA-directed RNA polymerase II core subunit RPO21 |
| Other Description | - |
| Swissprots | D6VRK8 Q12364 P04050 Q92315 |
| Accessions | 3RZD_A 3RZO_A 3S14_A 3S2D_A 3S2H_A 4X67_A 4X6A_A DAA11718 P04050 NM_001180200 NP_010141 |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcriptio |
| Subcellular Location | Nucleus. |
| Top Pathways | Purine metabolism, RNA polymerase, Pyrimidine metabolism |