| Gene Symbol |
SFPQ
|
| Entrez Gene |
6421
|
| Alt Symbol |
POMP100, PPP1R140, PSF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
splicing factor proline/glutamine-rich
|
| Other Description |
100 kDa DNA-pairing protein|DNA-binding p52/p100 complex, 100 kDa subunit|PTB-associated splicing factor|PTB-associated-splicing factor|hPOMp100|polypyrimidine tract binding protein associated|polypyrimidine tract-binding protein-associated splicing factor|polypyrimidine tract-binding protein-associated-splicing factor|protein phosphatase 1, regulatory subunit 140|splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)|splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated)|splicing factor, proline- and glutamine-rich
|
| Swissprots |
Q5SZ71 P30808 P23246
|
| Accessions |
EAX07421 EAX07422 EAX07423 EAX07424 EAX07425 EAX07426 P23246 AK095702 AK307985 AL831889 AL833670 BC000546 BC004534 AAH04534 BC027708 AAH27708 BC027717 BC051192 AAH51192 BX537811 X16850 CAA34747 X70944 CAA50283 XM_005271112 XP_005271169 XM_005271113 XP_005271170 XM_005271115 XP_005271172 XM_011541950 XP_011540252 NM_005066 NP_005057
|
| Function |
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nucle
|
| Subcellular Location |
Nucleus matrix. Cytoplasm. Note=Predominantly in nuclear matrix.
|
