SFPQ

Gene Symbol	SFPQ
Entrez Gene	6421
Alt Symbol	POMP100, PPP1R140, PSF
Species	Human
Gene Type	protein-coding
Description	splicing factor proline/glutamine-rich
Other Description	100 kDa DNA-pairing protein|DNA-binding p52/p100 complex, 100 kDa subunit|PTB-associated splicing factor|PTB-associated-splicing factor|hPOMp100|polypyrimidine tract binding protein associated|polypyrimidine tract-binding protein-associated splicing factor|polypyrimidine tract-binding protein-associated-splicing factor|protein phosphatase 1, regulatory subunit 140|splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)|splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated)|splicing factor, proline- and glutamine-rich
Swissprots	Q5SZ71 P30808 P23246
Accessions	EAX07421 EAX07422 EAX07423 EAX07424 EAX07425 EAX07426 P23246 AK095702 AK307985 AL831889 AL833670 BC000546 BC004534 AAH04534 BC027708 AAH27708 BC027717 BC051192 AAH51192 BX537811 X16850 CAA34747 X70944 CAA50283 XM_005271112 XP_005271169 XM_005271113 XP_005271170 XM_005271115 XP_005271172 XM_011541950 XP_011540252 NM_005066 NP_005057
Function	DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nucle
Subcellular Location	Nucleus matrix. Cytoplasm. Note=Predominantly in nuclear matrix.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SFPQ peptide - ab39323 from Abcam Category Peptide

SFPQ Antibody Blocking Peptide - LS-E2799 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SFPQ Antibody Blocking Peptide - LS-E14827 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SFPQ Blocking Peptide - LS-E27127 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SFPQ Protein - H00006421-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SFPQ-Antibody-C-term-Blocking-peptide - BP13903b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SFPQ Blocking Peptide - 33R-9727 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SFPQ Blocking Peptide - 33R-7413 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SFPQ / PSF - H00006421-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SFPQ / PSF - H00006421-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SFPQ fusion protein - Ag7181 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SFPQ, His-tagged - SFPQ-30711TH from Creative Biomart Category Protein Source E. coli

Recombinant Human SFPQ, His-tagged - SFPQ-2617H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Splicing factor, proline- and glutamine-rich(SFPQ) - CSB-YP021136HU CSB-EP021136HU CSB-BP021136HU CSB-MP021136HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human SFPQ protein, GST-tagged - SFPQ-856H from Creative Biomart Category Protein Source Wheat Germ Species Human

SFPQ Recombinant Protein Antigen - NBP2-49147PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

SFPQ Peptide, Human - M34GP14108H from Creative Peptides Category Peptide Source Synthetic. Species Human

SFPQ Recombinant Protein Antigen - NBP2-48876PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

Splicing factor, proline-and glutamine-rich (SFPQ), Recombinant Protein - MBS954071 from MyBioSource Category Protein Prices $1,515.00, $1,515.00, $1,740.00, $1,740.00, $2,595.00, $2,595.00, $3,035.00, $3,035.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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