| Gene Symbol | SFPQ |
|---|---|
| Entrez Gene | 6421 |
| Alt Symbol | POMP100, PPP1R140, PSF |
| Species | Human |
| Gene Type | protein-coding |
| Description | splicing factor proline/glutamine-rich |
| Other Description | 100 kDa DNA-pairing protein|DNA-binding p52/p100 complex, 100 kDa subunit|PTB-associated splicing factor|PTB-associated-splicing factor|hPOMp100|polypyrimidine tract binding protein associated|polypyrimidine tract-binding protein-associated splicing factor|polypyrimidine tract-binding protein-associated-splicing factor|protein phosphatase 1, regulatory subunit 140|splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)|splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated)|splicing factor, proline- and glutamine-rich |
| Swissprots | Q5SZ71 P30808 P23246 |
| Accessions | EAX07421 EAX07422 EAX07423 EAX07424 EAX07425 EAX07426 P23246 AK095702 AK307985 AL831889 AL833670 BC000546 BC004534 AAH04534 BC027708 AAH27708 BC027717 BC051192 AAH51192 BX537811 X16850 CAA34747 X70944 CAA50283 XM_005271112 XP_005271169 XM_005271113 XP_005271170 XM_005271115 XP_005271172 XM_011541950 XP_011540252 NM_005066 NP_005057 |
| Function | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nucle |
| Subcellular Location | Nucleus matrix. Cytoplasm. Note=Predominantly in nuclear matrix. |
PSF CRISPR/Cas9 KO Plasmid (h) - sc-402024 from Santa Cruz Biotechnology
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PSF HDR Plasmid (h) - sc-402024-HDR from Santa Cruz Biotechnology
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PSF Double Nickase Plasmid (h) - sc-402024-NIC from Santa Cruz Biotechnology
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PSF Double Nickase Plasmid (h2) - sc-402024-NIC-2 from Santa Cruz Biotechnology
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PSF CRISPR Activation Plasmid (h) - sc-402024-ACT from Santa Cruz Biotechnology
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PSF CRISPR Activation Plasmid (h2) - sc-402024-ACT-2 from Santa Cruz Biotechnology
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PSF Lentiviral Activation Particles (h) - sc-402024-LAC from Santa Cruz Biotechnology
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PSF Lentiviral Activation Particles (h2) - sc-402024-LAC-2 from Santa Cruz Biotechnology
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PSF siRNA (h) - sc-38304 from Santa Cruz Biotechnology
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PSF shRNA Plasmid (h) - sc-38304-SH from Santa Cruz Biotechnology
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PSF shRNA (h) Lentiviral Particles - sc-38304-V from Santa Cruz Biotechnology
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SFPQ RNAi - H00006421-R01 from Novus Biologicals
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MISSION® esiRNA - EHU071361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19195 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19195 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07002 from Sigma-Aldrich
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SFPQ siRNA (Human) - CRH4336 from Cohesion Biosciences
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SFPQ - MBS8224407 from MyBioSource
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shRNA set against Human Sfpq (NM_005066.2) - SHH405928 from Creative biogene
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Human SFPQ siRNA - orb264838 from Biorbyt
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SFPQ shRNA Plasmid (Human) - CHH4336 from Cohesion Biosciences
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SFPQ miRNA 3'UTR clone - MiUTR3H-07449 from Creative biogene
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