Gene Symbol |
HSP90B1
|
Entrez Gene |
7184
|
Alt Symbol |
ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
heat shock protein 90kDa beta (Grp94), member 1
|
Other Description |
94 kDa glucose-regulated protein|endoplasmin|endothelial cell (HBMEC) glycoprotein|epididymis luminal protein 35|epididymis secretory sperm binding protein Li 125m|heat shock protein 90 kDa beta member 1|stress-inducible tumor rejection antigen gp96|tumor rejection antigen (gp96) 1|tumor rejection antigen 1
|
Swissprots |
P14625 Q96A97
|
Accessions |
AAA58621 AAA68201 CAK18765 EAW97723 EAW97724 P14625 AB209534 BAD92771 AF087988 AJ890084 CAI64497 AK025459 AK025862 AK295262 BAG58251 AK298996 BAG61085 AK300521 BAG62233 AY040226 AAK74072 BC009195 AAH09195 BC066656 AAH66656 CA419931 EU794608 ACJ13662 FJ460515 ACS44652 S74942 AAD14161 X15187 CAA33261 NM_003299 NP_003290
|
Function |
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. {ECO:0000250, ECO:0000269|PubMed:18264092}.
|
Subcellular Location |
Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
|
Top Pathways |
Prostate cancer, NOD-like receptor signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Estrogen signaling pathway
|