Gene Symbol | IQSEC3 |
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Entrez Gene | 440073 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | IQ motif and Sec7 domain 3 |
Other Description | IQ motif and SEC7 domain-containing protein 3 |
Swissprots | Q8TB43 A6NKV9 A6NIF2 Q9UPP2 |
Accessions | EAW88980 EAW88981 EAW88982 EAW88983 EAW88984 Q9UPP2 AB029033 BAA83062 AK091953 BC024764 AAH24764 BC042067 XM_011520957 XP_011519259 XM_011520958 XP_011519260 XM_011520959 XP_011519261 XM_011520960 XP_011519262 XM_011520961 XP_011519263 XR_931511 XR_931512 XR_931513 NM_001170738 NP_001164209 NM_015232 NP_056047 |
Function | Acts as a guanine nucleotide exchange factor (GEF) for ARF1. {ECO:0000269|PubMed:17981261}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17981261}. |
Tissue Specificity | Expressed specifically in the adult brain, predominantly in the cerebral cortex and the olfactory bulb, but not in the fetal brain. Expressed only in mature neurons, but not in undifferentiated neural stem precursor cells (NSPCs), nor in glioma cells. {ECO:0000269|PubMed:17981261}. |
Top Pathways | Endocytosis |
IQSEC3 CRISPR/Cas9 KO Plasmid (h) - sc-409159 from Santa Cruz Biotechnology
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IQSEC3 HDR Plasmid (h) - sc-409159-HDR from Santa Cruz Biotechnology
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IQSEC3 Double Nickase Plasmid (h) - sc-409159-NIC from Santa Cruz Biotechnology
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IQSEC3 Double Nickase Plasmid (h2) - sc-409159-NIC-2 from Santa Cruz Biotechnology
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IQSEC3 CRISPR Activation Plasmid (h) - sc-409159-ACT from Santa Cruz Biotechnology
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IQSEC3 CRISPR Activation Plasmid (h2) - sc-409159-ACT-2 from Santa Cruz Biotechnology
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IQSEC3 Lentiviral Activation Particles (h) - sc-409159-LAC from Santa Cruz Biotechnology
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IQSEC3 Lentiviral Activation Particles (h2) - sc-409159-LAC-2 from Santa Cruz Biotechnology
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IQSEC3 siRNA (h) - sc-96232 from Santa Cruz Biotechnology
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IQSEC3 shRNA Plasmid (h) - sc-96232-SH from Santa Cruz Biotechnology
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IQSEC3 shRNA (h) Lentiviral Particles - sc-96232-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10758 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10758 from Sigma-Aldrich
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IQSEC3 siRNA (Human) - CRJ8232 from Cohesion Biosciences
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IQSEC3 - MBS8238439 from MyBioSource
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shRNA set against Human IQSEC3 (NM_015232.1) - SHH320461 from Creative biogene
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shRNA set against Human IQSEC3(NM_015232.1) - SHL180642 from Creative biogene
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Human IQSEC3 siRNA - orb278733 from Biorbyt
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IQSEC3 shRNA Plasmid (Human) - CHJ8232 from Cohesion Biosciences
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IQSEC3 miRNA 3'UTR clone - MiUTR1H-04985 from Creative biogene
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