GRIK2

Gene Symbol	GRIK2
Entrez Gene	2898
Alt Symbol	EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6
Species	Human
Gene Type	protein-coding
Description	glutamate receptor, ionotropic, kainate 2
Other Description	bA487F5.1\|excitatory amino acid receptor 4\|gluR-6\|glutamate receptor 6\|glutamate receptor form A\|glutamate receptor form B\|glutamate receptor form C\|glutamate receptor form D\|glutamate receptor form E\|glutamate receptor ionotropic, kainate 2
Swissprots	D7RWZ4 Q13002 D7RWZ3 Q96KS8 Q8WWS1 Q96KS6 D7RWZ6 A6NMY9 Q96KS7 B5MCV0 D7RWZ7 D7RWZ5
Accessions	CAC25104 CCQ43905 EAW48446 EAW48447 EAW48448 Q13002 AI087397 AJ252246 CAC81020 AJ301608 CAC67485 AJ301609 CAC67486 AJ301610 CAC67487 AK023497 AK289542 BAF82231 AK291965 BAF84654 AK303721 BAH14032 AW949408 BC037954 AAH37954 BC063814 AAH63814 BM722353 BQ717946 HM149335 ADH93569 HM149336 ADH93570 HM149337 ADH93571 HM149338 ADH93572 HM149339 ADH93573 HM149340 ADH93574 JF432691 ADZ15908 S75105 U16126 AAC50420 XM_005266945 XP_005267002 XM_005266946 XP_005267003 XM_011535777 XP_011534079 XM_011535778 XP_011534080 XM_011535779 XP_011534081 XM_011535780 XP_011534082 XM_011535781 XP_011534083 NM_001166247 NP_001159719 NM_021956 NP_068775 NM_175768 NP_786944
Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expression is higher in cerebellum than in cerebral cortex.
Top Pathways	Glutamatergic synapse, Neuroactive ligand-receptor interaction

GluR-6 (C-18) - sc-7618 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

GluR-6 (C-18): sc-7618. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells.

GluR-6 (I-14) - sc-26476 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

GluR-6 (S-13) - sc-26478 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

GluR-6 (S-13): sc-26478. Western blot analysis of GluR-6 expression in IMR-32 whole cell lysate.

Anti-GRIK2 antibody - ab53092 from Abcam

Prices	$384.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-GRIK2 antibody (ab53092) at 1/300 dilutionLane 1 : Mouse brain extractsLane 2 : Mouse brain extracts with immunizing peptide

Anti-GRIK2 antibody - ab185685 from Abcam

Prices	$378.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab185685. Blue DAPI for nuclear staining.

Anti-GRIK2 antibody - ab66440 from Abcam

Prices	$378.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ICC/IF image of ab66440 stained SHSY5Y cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab66440, 1/1000 dilution) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-GRIK2 antibody - ab67318 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Lane 1 : Anti-GRIK2 antibody (ab67318) at 0.5 µg/mlLane 2 : Anti-GRIK2 antibody (ab67318) at 1 µg/mlLane 1 : human brain tissue lysateLane 2 : human brain tissue lysateLysates/proteins at 15 µg per lane.

Anti-GRIK2 antibody - ab169498 from Abcam

Prices	$376.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-GRIK2 antibody (ab169498) at 1/500 dilutionLane 1 : GRIK2 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-GRIK2 antibody - ab28697 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 antibody (ab28697) at 2.5 µg/ml + Jurkat cell lysateSecondaryHRP conjugated anti-Rabbit IgG

Anti-GRIK2 antibody [EPR6307] - ab124702 from Abcam

Prices	$387.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR6307

All lanes : Anti-GRIK2 antibody [EPR6307] (ab124702) at 1/1000 dilutionLane 1 : Human fetal brain lysateLane 2 : Human kidney lysateLane 3 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-GRIK2 antibody - C-terminal - ab182110 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 antibody - C-terminal (ab182110) at 1 µg/ml + Human ACHN whole cell lysates at 10 µg

Anti-GLUR6/7 Antibody (C-Terminus) - LS-C125944 from LifeSpan Bioscience

Prices	$530.00
Sizes	500 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GLUR6/7 Antibody (C-Terminus) - LS-C189032 from LifeSpan Bioscience

Prices	$425.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 / GLUR6 Antibody (aa827-856, FITC) - LS-C214950 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 / GLUR6 Antibody (aa827-856, APC) - LS-C214948 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 / GLUR6 Antibody (aa827-856, Biotin) - LS-C214949 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 / GLUR6 Antibody (aa827-856, Azide-free, HRP) - LS-C214951 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 / GLUR6 Antibody (aa827-856, PE) - LS-C214953 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 / GLUR6 Antibody (aa827-856) - LS-C329604 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 / GLUR6 Antibody (aa151-200) - LS-C30845 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

GRIK2 antibody LS-C30845 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-GRIK2 / GLUR6 Antibody - LS-C341384 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GRIK2 / GLUR6 Antibody (C-Terminus) - LS-C53225 from LifeSpan Bioscience

Prices	$325.00, $890.00
Sizes	50 µg, 500 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Grik2 in human brain tissue lysate with Grik2 antibody at (A) 0.5 and (B) 1 ug/ml.

Anti-GRIK2 / GLUR6 Antibody (aa478-527) - LS-C201308 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Human ACHN. GRIK2 antibody dilution 1.0 ug/ml.

Anti-GRIK2 / GLUR6 Antibody (aa828-856) - LS-C166673 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

GRIK2 Antibody western blot of A549 cell line lysates (35 ug/lane). The GRIK2 antibody detected the GRIK2 protein (arrow).

Anti-GRIK2 / GLUR6 Antibody (Extracellular Domain, clone EPR6307) IHC-plus™ - LS-B9972 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR6307

Anti-GRIK2 / GLUR6 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9972 dilution 1:100.

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