LGALS3
| Gene Symbol | LGALS3 |
|---|---|
| Entrez Gene | 3958 |
| Alt Symbol | CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lectin, galactoside-binding, soluble, 3 |
| Other Description | 35 kDa lectin|IgE-binding protein|MAC-2 antigen|carbohydrate-binding protein 35|galactose-specific lectin 3|galectin-3|laminin-binding protein|lectin L-29 |
| Swissprots | B2RC38 P17931 Q96J47 Q6IBA7 Q16005 |
| Accessions | AAB86584 BAC45249 CBX53892 EAW80658 EAW80660 P17931 AB006780 BAA22164 AB209391 BAD92628 AF266280 AAG44701 AK314929 BAG37435 BC001120 AAH01120 BC053667 AAH53667 BC068068 AAH68068 BC128253 BC128403 BG332134 BQ645629 BU681070 BX161455 CAD61918 BX641090 CAE46042 CD518618 CR456897 CAG33178 CR542097 CAG46894 DQ892594 ABM83520 EU176706 ABW03507 M35368 AAA88086 M36682 AAA36163 M57710 AAA35607 M64303 S59012 AAB26229 XM_011536759 XP_011535061 NM_001177388 NP_001170859 NM_002306 NP_002297 NR_003225 |
| Function | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635, ECO:0000269|PubMed:19616076}. |
| Subcellular Location | Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. |
| Tissue Specificity | A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. {ECO:0000269|PubMed:19497882}. |
galectin-3 CRISPR/Cas9 KO Plasmid (h) - sc-417680 from Santa Cruz Biotechnology
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galectin-3 HDR Plasmid (h) - sc-417680-HDR from Santa Cruz Biotechnology
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galectin-3 Double Nickase Plasmid (h) - sc-417680-NIC from Santa Cruz Biotechnology
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galectin-3 Double Nickase Plasmid (h2) - sc-417680-NIC-2 from Santa Cruz Biotechnology
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galectin-3 CRISPR Activation Plasmid (h) - sc-417680-ACT from Santa Cruz Biotechnology
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galectin-3 CRISPR Activation Plasmid (h2) - sc-417680-ACT-2 from Santa Cruz Biotechnology
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galectin-3 Lentiviral Activation Particles (h) - sc-417680-LAC from Santa Cruz Biotechnology
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galectin-3 Lentiviral Activation Particles (h2) - sc-417680-LAC-2 from Santa Cruz Biotechnology
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galectin-3 siRNA (h) - sc-155994 from Santa Cruz Biotechnology
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galectin-3 shRNA Plasmid (h) - sc-155994-SH from Santa Cruz Biotechnology
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galectin-3 shRNA (h) Lentiviral Particles - sc-155994-V from Santa Cruz Biotechnology
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Galectin-3 RNAi - H00003958-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN11667 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11667 from Sigma-Aldrich
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LGALS3 siRNA (Human) - CRH2681 from Cohesion Biosciences
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Galectin-3 RNAi - H00003958-R01 from Novus Biologicals
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shRNA set against Human LGALS3 (NM_002306.3) - SHH329799 from Creative biogene
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Human Galectin 3 siRNA - orb263183 from Biorbyt
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LGALS3 shRNA Plasmid (Human) - CHH2681 from Cohesion Biosciences
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LGALS3 miRNA 3'UTR clone - MiUTR3H-01366 from Creative biogene
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