Gene Symbol | Mcpt4 |
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Entrez Gene | 17227 |
Alt Symbol | MMCP-4, MMCP-4A, MMCP-4B, Mcp-4, Mcp4 |
Species | Mouse |
Gene Type | protein-coding |
Description | mast cell protease 4 |
Other Description | MSMCP|myonase|serosal mast cell protease |
Swissprots | P21812 Q9EQT2 Q9EPQ9 |
Accessions | AAA72939 EDL36217 EDL36218 P21812 AB051900 BAB18732 AK144385 BAE25859 AV018388 AY007569 AAG24503 BC026198 AAH26198 CJ046459 M55617 AAA39989 X68804 CAA48704 NM_010779 NP_034909 |
Function | Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta- protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. {ECO:0000269|PubMed:12900518, ECO:0000269|PubMed:9538257}. |
Tissue Specificity | Submucosal mast cells. In femoral muscle, detected in myocytes but not in mast cells. {ECO:0000269|PubMed:9538257}. |
Mast Cell Protease 4 CRISPR/Cas9 KO Plasmid (m) - sc-421600 from Santa Cruz Biotechnology
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Mast Cell Protease 4 HDR Plasmid (m) - sc-421600-HDR from Santa Cruz Biotechnology
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Mast Cell Protease 4 Double Nickase Plasmid (m) - sc-421600-NIC from Santa Cruz Biotechnology
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Mast Cell Protease 4 Double Nickase Plasmid (m2) - sc-421600-NIC-2 from Santa Cruz Biotechnology
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Mast Cell Protease 4 CRISPR Activation Plasmid (m) - sc-421600-ACT from Santa Cruz Biotechnology
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Mast Cell Protease 4 CRISPR Activation Plasmid (m2) - sc-421600-ACT-2 from Santa Cruz Biotechnology
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Mast Cell Protease 4 Lentiviral Activation Particles (m) - sc-421600-LAC from Santa Cruz Biotechnology
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Mast Cell Protease 4 Lentiviral Activation Particles (m2) - sc-421600-LAC-2 from Santa Cruz Biotechnology
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Mast Cell Protease 4 siRNA (m) - sc-149283 from Santa Cruz Biotechnology
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Mast Cell Protease 4 shRNA Plasmid (m) - sc-149283-SH from Santa Cruz Biotechnology
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Mast Cell Protease 4 shRNA (m) Lentiviral Particles - sc-149283-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN35383 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35383 from Sigma-Aldrich
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MCPT4 siRNA (Mouse) - CRM2494 from Cohesion Biosciences
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shRNA set against Mouse Mcpt4 (NM_010779.2) - SHH339471 from Creative biogene
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shRNA set against Mouse Mcpt4(NM_010779.2) - SHH181919 from Creative biogene
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Mouse MCPT4 siRNA - orb281970 from Biorbyt
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MCPT4 shRNA Plasmid (Mouse) - CHM2494 from Cohesion Biosciences
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MCPT4 miRNA 3'UTR clone - MiUTR1M-07010 from Creative biogene
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