Gene Symbol | ADAM2 |
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Entrez Gene | 2515 |
Alt Symbol | CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta |
Species | Human |
Gene Type | protein-coding |
Description | ADAM metallopeptidase domain 2 |
Other Description | cancer/testis antigen 15|disintegrin and metalloproteinase domain-containing protein 2|fertilin subunit beta |
Swissprots | Q9UQQ8 P78326 Q99965 |
Accessions | CBH30599 EAW63273 EAW63274 EAW63275 Q99965 AJ133005 CAB40813 AK301734 BAG63199 BC034957 AAH34957 BC064547 AAH64547 BG719616 BI460477 DQ891615 ABM82541 DQ894807 ABM85733 U38805 AAD04206 U52370 AAC51110 X99374 CAA67753 XM_005273468 XP_005273525 XM_006725119 XP_006725182 XM_011544479 XP_011542781 XM_011544480 XP_011542782 XM_011546571 XP_011544873 XM_011546572 XP_011544874 NM_001278113 NP_001265042 NM_001278114 NP_001265043 NM_001464 NP_001455 |
Function | Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues. |
ADAM2 CRISPR/Cas9 KO Plasmid (h) - sc-409614 from Santa Cruz Biotechnology
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ADAM2 HDR Plasmid (h) - sc-409614-HDR from Santa Cruz Biotechnology
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ADAM2 Double Nickase Plasmid (h) - sc-409614-NIC from Santa Cruz Biotechnology
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ADAM2 Double Nickase Plasmid (h2) - sc-409614-NIC-2 from Santa Cruz Biotechnology
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ADAM2 CRISPR Activation Plasmid (h) - sc-409614-ACT from Santa Cruz Biotechnology
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ADAM2 CRISPR Activation Plasmid (h2) - sc-409614-ACT-2 from Santa Cruz Biotechnology
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ADAM2 Lentiviral Activation Particles (h) - sc-409614-LAC from Santa Cruz Biotechnology
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ADAM2 Lentiviral Activation Particles (h2) - sc-409614-LAC-2 from Santa Cruz Biotechnology
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ADAM2 siRNA (h) - sc-41402 from Santa Cruz Biotechnology
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ADAM2 shRNA Plasmid (h) - sc-41402-SH from Santa Cruz Biotechnology
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ADAM2 shRNA (h) Lentiviral Particles - sc-41402-V from Santa Cruz Biotechnology
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ADAM2 RNAi - H00002515-R01 from Novus Biologicals
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MISSION® esiRNA - EHU086941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2809 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2809 from Sigma-Aldrich
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ADAM2 siRNA (Human) - CRH1662 from Cohesion Biosciences
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ADAM2 - MBS8203214 from MyBioSource
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shRNA set against Human ADAM2 (NM_001464.3) - SHH231486 from Creative biogene
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shRNA set against Human ADAM2(NM_001464.3) - SHG038393 from Creative biogene
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ADAM2 shRNA Plasmid (Human) - CHH1662 from Cohesion Biosciences
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ADAM2 miRNA 3'UTR clone - MiUTR1H-00157 from Creative biogene
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