a

Gene Symbol a
Entrez Gene 50518
Alt Symbol A<y>, ASIP, ASP, As
Species Mouse
Gene Type protein-coding
Description nonagouti
Other Description agouti coat color protein|agouti signal protein|agouti switch protein|agouti-signaling protein|non-agouti
Swissprots A2ALT3 Q03288 Q80ST0
Accessions EDL06104 EDL06105 EDL06106 Q03288 AK156952 AK172452 BC009122 L06451 AAA37201 L06452 L06941 S63413 AAA15908 S70320 AAP19635 S70326 AAP19636 S70394 AAP19637 S74479 AAP31517 S74489 AAP31519 S74493 AAP31520 XM_011239689 XP_011237991 XM_011239690 XP_011237992 XM_011239691 XP_011237993 XM_011251809 XP_011250111 XM_011251810 XP_011250112 XR_375144 XR_375145 XR_375146 XR_375149 XR_400376 XR_400377 XR_400378 XR_400381 XR_866315 XR_866316 XR_866317 XR_866319 XR_866320 XR_866321 XR_866322 XR_886317 XR_886318 XR_886319 XR_886320 XR_886321 XR_886322 XR_886323 NM_015770 NP_056585
Function Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.
Subcellular Location Secreted.
Tissue Specificity Epithelial cells of the hair follicles and the epidermis.
Top Pathways Melanogenesis

agouti signaling protein, nonagouti homolog (mouse) , ELISA Kit - MBS914489 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of mouse ASIP is typically less than 11.7 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 47 pg/ml -3000 pg/ml.

Mouse Agouti-signaling protein(ASIP) ELISA kit - CSB-EL002212MO from Cusabio

Category ELISA Kit
Sensitivity 11.7 pg/ml
Range 47 pg/ml-3000 pg/ml

Mouse A ELISA Kit - E062492 from Biobool

Category ELISA Kit

ASIP ELISA Kit (Mouse) (OKCA00875) - OKCA00875 from Aviva Systems Biology

Category ELISA Kit
Prices $590.00
Sizes 96 wells
Sensitivity 11.7 pg/mL
Range 47 pg/mL-3,000 pg/mL
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