| Gene Symbol |
GAPT
|
| Entrez Gene |
202309
|
| Alt Symbol |
C5orf29
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GRB2-binding adaptor protein, transmembrane
|
| Other Description |
GRB2-binding transmembrane adaptor|growth factor receptor-bound protein 2-binding adapter protein, transmembrane|protein GAPT
|
| Swissprots |
Q8N292
|
| Accessions |
CAC38692 CAD48812 EAW54974 EAW54975 Q8N292 AA220230 AK090960 BAC03557 BC063534 AAH63534 DA008727 DA347824 NM_001304428 NP_001291357 NM_001304429 NP_001291358 NM_001304431 NP_001291360 NM_152687 NP_689900
|
| Function |
Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18559951}; Single-pass membrane protein {ECO:0000269|PubMed:18559951}.
|
| Tissue Specificity |
Highly expressed in spleen and PBL, detected at lower levels in thymus, and undetectable in all other tissues tested. Also expressed in various B-cell lines, monocytic cell line THP-1 and NK-like cell line YT, but not in T-cell line Jurkat or HeLa cells. {ECO:0000269|PubMed:18559951}.
|
![Western Blot: GAPT Overexpression Lysate (Adult Normal) [NBL1-08489] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GAPT.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1052_GAPT%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08489-img0002.jpg)