Gene Symbol | GAPT |
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Entrez Gene | 202309 |
Alt Symbol | C5orf29 |
Species | Human |
Gene Type | protein-coding |
Description | GRB2-binding adaptor protein, transmembrane |
Other Description | GRB2-binding transmembrane adaptor|growth factor receptor-bound protein 2-binding adapter protein, transmembrane|protein GAPT |
Swissprots | Q8N292 |
Accessions | CAC38692 CAD48812 EAW54974 EAW54975 Q8N292 AA220230 AK090960 BAC03557 BC063534 AAH63534 DA008727 DA347824 NM_001304428 NP_001291357 NM_001304429 NP_001291358 NM_001304431 NP_001291360 NM_152687 NP_689900 |
Function | Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:18559951}; Single-pass membrane protein {ECO:0000269|PubMed:18559951}. |
Tissue Specificity | Highly expressed in spleen and PBL, detected at lower levels in thymus, and undetectable in all other tissues tested. Also expressed in various B-cell lines, monocytic cell line THP-1 and NK-like cell line YT, but not in T-cell line Jurkat or HeLa cells. {ECO:0000269|PubMed:18559951}. |
GAPT CRISPR/Cas9 KO Plasmid (h) - sc-415027 from Santa Cruz Biotechnology
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GAPT HDR Plasmid (h) - sc-415027-HDR from Santa Cruz Biotechnology
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GAPT Double Nickase Plasmid (h) - sc-415027-NIC from Santa Cruz Biotechnology
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GAPT Double Nickase Plasmid (h2) - sc-415027-NIC-2 from Santa Cruz Biotechnology
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GAPT CRISPR Activation Plasmid (h) - sc-415027-ACT from Santa Cruz Biotechnology
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GAPT CRISPR Activation Plasmid (h2) - sc-415027-ACT-2 from Santa Cruz Biotechnology
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GAPT Lentiviral Activation Particles (h) - sc-415027-LAC from Santa Cruz Biotechnology
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GAPT Lentiviral Activation Particles (h2) - sc-415027-LAC-2 from Santa Cruz Biotechnology
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GAPT siRNA (h) - sc-91636 from Santa Cruz Biotechnology
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GAPT shRNA Plasmid (h) - sc-91636-SH from Santa Cruz Biotechnology
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GAPT shRNA (h) Lentiviral Particles - sc-91636-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU131161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9130 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9130 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09484 from Sigma-Aldrich
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GAPT siRNA (Human) - CRJ6316 from Cohesion Biosciences
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GAPT - MBS8208691 from MyBioSource
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shRNA set against Human GAPT (NM_152687.2) - SHH299321 from Creative biogene
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Human GAPT siRNA - orb276817 from Biorbyt
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GAPT shRNA Plasmid (Human) - CHJ6316 from Cohesion Biosciences
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GAPT miRNA 3'UTR clone - MiUTR1H-01420 from Creative biogene
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