ST14

Gene Symbol ST14
Entrez Gene 6768
Alt Symbol ARCI11, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14
Species Human
Gene Type protein-coding
Description suppression of tumorigenicity 14 (colon carcinoma)
Other Description membrane-type serine protease 1|prostamin|serine protease 14|serine protease TADG-15|suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)|suppressor of tumorigenicity 14 protein|tumor associated differentially expressed gene 15 protein|tumor-associated differentially-expressed gene 15 protein
Swissprots Q9HCA3 Q9BS01 Q9Y5Y6 Q9HB36 Q9H3S0
Accessions AAG13949 EAW67776 Q9Y5Y6 AB030036 BAB20376 AF057145 AAG15395 AF118224 AAD42765 AF133086 AAF00109 AK302454 BAG63749 AK314173 BAG36856 BC005826 AAH05826 BC018146 AAH18146 BC030532 AAH30532 BM791311 BQ059215 DQ891626 ABM82552 DQ894442 ABM85368 NM_021978 NP_068813
Function Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. {ECO:0000269|PubMed:18843291}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Top Pathways MicroRNAs in cancer

Matriptase (D-7) - sc-365482 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Matriptase (D-7): sc-365482. Western blot analysis of Matriptase expression in Ramos whole cell lysate.

Matriptase (C-16) - sc-25235 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Matriptase (H-270) - sc-48830 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Matriptase (H-270): sc-48830. Western blot analysis of Matriptase expression in non-transfected: sc-117752 (A) and human Matriptase transfected: sc-170663 (B) 293T whole cell lysates.

Matriptase (L-18) - sc-25234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Matriptase (L-18): sc-25234. Western blot analysis of Matriptase expression in Jurkat (A), A549 (B) and HL-60 (C) whole cell lysates.

Anti-ST14 antibody - ab28267 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ST14 antibody (ab28267) at 1/2500 dilution + Hela Whole Cell Lysate - Staurosporine Treated (48hr, 500nM) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-ST14 antibody - ab73568 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ST14 antibody - Aminoterminal end cleaved protein - ab28265 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ST14 antibody - Catalytic domain - ab28266 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab28266 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab28266, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-ST14 antibody - Catalytic domain - ab59779 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ST14 antibody - Catalytic domain (ab59779) at 1/1000 dilutionLane 1 : Whole cell lysate from human prostate cancer DU145 cellsLane 2 : Whole cell lysate from human prostate cancer DU145 cellsLane 3 : Whole cell lysate prepared from human embryonic kidney HEK293 cellsLane 4 : Whole cell lysate prepared from human embryonic kidney HEK293 cells

Anti-ST14 antibody - CUB-2 domain - ab65880 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ST14 antibody - CUB-2 domain (ab65880) at 1/5000 dilutionLane 1 : SK HEP 1 lysate. Treated for 48 hours 10 ng/mL of IL1-betaLane 2 : SK HEP 1 lysate. Treated for 48 hours 10 ng/mL of IL1-beta. Lane 3 : SK HEP 1 lysate. Treated for 48 hours 10 ng/mL of IL1-beta. Lane 4 : SW 620 lysate. Treated for 48 hours 10 ng/mL of IL1-alpha. Lane 5 : SW 620 lysate. Treated for 48 hours 10 ng/mL of IL1-alpha. Performed under non-reducing conditions.

Anti-ST14 antibody - Cytoplasmic domain - ab28268 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ST14 / Matriptase Antibody (clone 2F4) - LS-C198273 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4
Detection limit for recombinant GST tagged ST14 is approximately 1 ng/ml as a capture antibody.

Anti-ST14 / Matriptase Antibody (aa826-855, PE) - LS-C224153 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ST14 / Matriptase Antibody (aa736-785) - LS-C81148 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ST14 / Matriptase antibody LS-C81148 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-ST14 / Matriptase Antibody (aa826-855, Azide-free, HRP) - LS-C224151 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ST14 / Matriptase Antibody (aa607-852, Biotin) - LS-C299812 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-ST14 / Matriptase Antibody (aa607-852, Biotin) - LS-C300600 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ST14 / Matriptase Antibody (aa607-852, FITC) - LS-C305003 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ST14 / Matriptase Antibody (aa607-852, FITC) - LS-C304408 from LifeSpan Bioscience

Prices $485.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-ST14 / Matriptase Antibody (aa826-855) - LS-C325411 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ST14 / Matriptase Antibody (C-Terminus) - LS-C287140 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of human Matriptase/ST14 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (30 ug for WB; 500 ug for IP/WB) from MCF7 cells. Antibody: Affinity purified rabbit anti-Matriptase/ST14 antibody used at 1 ug/ml for WB and at 10 ug/mg lysate for IP. Detection: Chemiluminescence with exposure times of less than 15 min.

Anti-ST14 / Matriptase Antibody - LS-C146994 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ST14 / Matriptase antibody LS-C146994.

Anti-ST14 / Matriptase Antibody (aa607-852) - LS-C296547 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant ST14 / Matriptase.

Anti-ST14 / Matriptase Antibody (aa607-852) - LS-C292519 from LifeSpan Bioscience

Prices $445.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant ST14 / Matriptase.

Anti-ST14 / Matriptase Antibody (aa10-59) IHC-plus™ - LS-B4906 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ST14 / Matriptase antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4906 concentration 10 ug/ml.
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