| Gene Symbol |
ST14
|
| Entrez Gene |
6768
|
| Alt Symbol |
ARCI11, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppression of tumorigenicity 14 (colon carcinoma)
|
| Other Description |
membrane-type serine protease 1|prostamin|serine protease 14|serine protease TADG-15|suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)|suppressor of tumorigenicity 14 protein|tumor associated differentially expressed gene 15 protein|tumor-associated differentially-expressed gene 15 protein
|
| Swissprots |
Q9HCA3 Q9BS01 Q9Y5Y6 Q9HB36 Q9H3S0
|
| Accessions |
AAG13949 EAW67776 Q9Y5Y6 AB030036 BAB20376 AF057145 AAG15395 AF118224 AAD42765 AF133086 AAF00109 AK302454 BAG63749 AK314173 BAG36856 BC005826 AAH05826 BC018146 AAH18146 BC030532 AAH30532 BM791311 BQ059215 DQ891626 ABM82552 DQ894442 ABM85368 NM_021978 NP_068813
|
| Function |
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. {ECO:0000269|PubMed:18843291}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Top Pathways |
MicroRNAs in cancer
|
![Western Blot: ST14 Overexpression Lysate (Adult Normal) [NBP2-06488] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ST14.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6042_ST14%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06488-img0001.jpg)