Gene Symbol | DCTPP1 |
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Entrez Gene | 79077 |
Alt Symbol | CDA03, RS21C6, XTP3TPA |
Species | Human |
Gene Type | protein-coding |
Description | dCTP pyrophosphatase 1 |
Other Description | XTP3-transactivated gene A protein|XTP3-transactivated protein A|dCTPase 1|deoxycytidine-triphosphatase 1 |
Swissprots | Q9H773 |
Accessions | EAW52247 Q9H773 AF210430 AAK48422 AF212242 AAK14927 AK024843 BAB15025 AY453409 AAR26724 BC001344 AAH01344 CR457335 CAG33616 NM_024096 NP_077001 |
Function | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Top Pathways | Pyrimidine metabolism |
XTP3TPA (N-12) - sc-132505 from Santa Cruz Biotechnology
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XTP3TPA (B-6) - sc-398501 from Santa Cruz Biotechnology
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XTP3TPA (C-15) - sc-132501 from Santa Cruz Biotechnology
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XTP3TPA (G-23) - sc-102159 from Santa Cruz Biotechnology
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Anti-XTP3TPA antibody - ab168161 from Abcam
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Anti-XTP3TPA antibody - ab176967 from Abcam
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Anti-XTP3TPA antibody - N-terminal - ab80172 from Abcam
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Anti-DCTPP1 / XTP3TPA Antibody (N-Terminus) - LS-C80879 from LifeSpan Bioscience
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Anti-DCTPP1 / XTP3TPA Antibody (C-Terminus) - LS-C80880 from LifeSpan Bioscience
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Anti-DCTPP1 / XTP3TPA Antibody (aa12-40) IHC-plus⢠- LS-B7779 from LifeSpan Bioscience
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XTP3TPA Antibody - NBP1-85736 from Novus Biologicals
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XTP3TPA Antibody - NBP1-55335 from Novus Biologicals
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XTP3TPA Antibody - H00079077-B01 from Novus Biologicals
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Anti-DCTPP1 antibody produced in rabbit - HPA002832 from Sigma-Aldrich
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Anti-XTP3TPA (AB1) antibody produced in rabbit - AV46329 from Sigma-Aldrich
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Anti-XTP3TPA (AB2) antibody produced in rabbit - AV46328 from Sigma-Aldrich
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XTP3TPA antibody - N-terminal region (ARP46328_T100) - ARP46328_T100 from Aviva Systems Biology
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XTP3TPA antibody - middle region (ARP46329_P050) - ARP46329_P050 from Aviva Systems Biology
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DCTPP1 Antibody - N-terminal region (OAAB01536) - OAAB01536 from Aviva Systems Biology
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XTP3TPA-Antibody-N-term - AP2821a from Abgent, a WuXi AppTec company
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DCTPP1 antibody [N1C3] - GTX119837 from GeneTex
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XTP3TPA antibody - 70R-1225 from Fitzgerald
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XTP3TPA Antibody - abx036082 from Abbexa
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XTP3TPA Antibody - abx031729 from Abbexa
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XTP3TPA / DCTPP1 antibody - 16684-1-AP from Acris Antibodies
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