Gene Symbol | DCTPP1 |
---|---|
Entrez Gene | 79077 |
Alt Symbol | CDA03, RS21C6, XTP3TPA |
Species | Human |
Gene Type | protein-coding |
Description | dCTP pyrophosphatase 1 |
Other Description | XTP3-transactivated gene A protein|XTP3-transactivated protein A|dCTPase 1|deoxycytidine-triphosphatase 1 |
Swissprots | Q9H773 |
Accessions | EAW52247 Q9H773 AF210430 AAK48422 AF212242 AAK14927 AK024843 BAB15025 AY453409 AAR26724 BC001344 AAH01344 CR457335 CAG33616 NM_024096 NP_077001 |
Function | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Top Pathways | Pyrimidine metabolism |