| Gene Symbol | SIRT4 |
|---|---|
| Entrez Gene | 519328 |
| Alt Symbol | - |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | sirtuin 4 |
| Other Description | NAD-dependent deacetylase sirtuin-4|NAD-dependent protein deacetylase sirtuin-4 |
| Swissprots | Q1JQC6 |
| Accessions | DAA20626 Q1JQC6 BC116055 AAI16056 GQ166650 ACS66700 XM_005217844 XP_005217901 XM_005217845 XP_005217902 XM_005217846 XP_005217903 XM_005217847 XP_005217904 XM_010813926 XP_010812228 NM_001075785 NP_001069253 |
| Function | Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion. {ECO:0000255|HAMAP-Rule:MF_03161}. |
| Subcellular Location | Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03161}. |
Recombinant Bovine NAD-dependent protein deacetylase sirtuin-4(SIRT4) - CSB-YP628201BO CSB-EP628201BO CSB-BP628201BO CSB-MP628201BO from Cusabio
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NAD-dependent protein deacetylase sirtuin-4 (SIRT4), Recombinant Protein - MBS1310973 from MyBioSource
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