| Gene Symbol | GRIN2B |
|---|---|
| Entrez Gene | 2904 |
| Alt Symbol | EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, hNR3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| Other Description | N-methyl D-aspartate receptor subtype 2B|N-methyl-D-aspartate receptor subunit 3|NR3|glutamate [NMDA] receptor subunit epsilon-2|glutamate receptor ionotropic, NMDA 2B|glutamate receptor subunit epsilon-2 |
| Swissprots | Q12919 Q14CU4 Q13225 Q9UM56 Q13224 Q13220 |
| Accessions | EAW96311 Q13224 AB208850 BAD92087 AK091524 BC113618 AAI13619 BC113620 AAI13621 BX648060 U11287 AAB60368 U28758 AAA74930 U28861 AAA69919 U28862 AAA69920 U88963 AAD00659 U90278 AAB49993 XM_005253351 XP_005253408 XM_011520628 XP_011518930 XM_011520629 XP_011518931 XM_011520630 XP_011518932 NM_000834 NP_000825 |
| Function | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. {ECO:0000269|PubMed:9547169}. |
| Top Pathways | Rap1 signaling pathway, Circadian entrainment, Alcoholism, Cocaine addiction, cAMP signaling pathway |