| Gene Symbol | Tgm3 |
|---|---|
| Entrez Gene | 21818 |
| Alt Symbol | AI893889, TG E, TG(E), TGE, TGase E, TGase-3 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | transglutaminase 3, E polypeptide |
| Other Description | E polypeptide|protein-glutamine gamma-glutamyltransferase E|protein-glutamine-gamma-glutamyltransferase|transglutaminase E|transglutaminase-3 |
| Swissprots | A2ANC3 A1L343 Q08189 |
| Accessions | EDL28248 Q08189 AK036783 BC129890 AAI29891 BC129891 AAI29892 L10385 AAA40421 XM_006499151 XP_006499214 XM_011239437 XP_011237739 NM_009374 NP_033400 |
| Function | Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath. {ECO:0000250}. |
| Tissue Specificity | Expressed in skin and stomach and, at lower levels, in testis, kidney and spleen (at protein level). On the basis of its catalytic activity, detected in the epidermis, around the granular and spinous layers but not in the outermost cornified layers. In hair follicles, mainly located in the medulla and the hair cortex. {ECO:0000269|PubMed:11331204, ECO:0000269|PubMed:20716179}. |