| Gene Symbol |
PTPLAD1
|
| Entrez Gene |
100125237
|
| Alt Symbol |
HACD3
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase-like A domain containing 1
|
| Other Description |
3-hydroxyacyl-CoA dehydratase 3|protein tyrosine phosphatase-like protein PTPLAD1|protein-tyrosine phosphatase-like A domain-containing protein 1|very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3|very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
|
| Swissprots |
A7YY55
|
| Accessions |
A7YY55 DAA25698 BC151339 AAI51340 NM_001103316 NP_001096786
|
| Function |
Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1-signaling pathways leading to the modulation of gene expression. {ECO:0000250|UniProtKB:Q9P035}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9P035}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9P035}.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism
|