Gene Symbol | KDELR1 |
---|---|
Entrez Gene | 10945 |
Alt Symbol | ERD2, ERD2.1, HDEL, PM23 |
Species | Human |
Gene Type | protein-coding |
Description | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 |
Other Description | ER lumen protein retaining receptor 1|ER lumen protein-retaining receptor 1|KDEL endoplasmic reticulum protein retention receptor 1|KDEL receptor 1|putative MAPK-activating protein PM23 |
Swissprots | Q54A39 B2R6N4 Q8NBW7 P24390 |
Accessions | EAW52340 EAW52341 EAW52342 EAW52343 EAW52344 EAW52345 P24390 AB097047 BAC77400 AK075185 BAC11457 AK312647 BAG35531 BC008958 AAH08958 BC018778 AAH18778 DQ891992 ABM82918 DQ895182 ABM86108 X55885 CAA39371 XM_011526358 XP_011524660 NM_006801 NP_006792 |
Function | Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. {ECO:0000269|PubMed:11703931}. |
Subcellular Location | Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:14517323}; Multi-pass membrane protein {ECO:0000269|PubMed:14517323}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14517323}; Multi-pass membrane protein {ECO:0000269|PubMed:14517323}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:14517323}. |
Top Pathways | Vibrio cholerae infection |