Gene Symbol | KDELR1 |
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Entrez Gene | 10945 |
Alt Symbol | ERD2, ERD2.1, HDEL, PM23 |
Species | Human |
Gene Type | protein-coding |
Description | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 |
Other Description | ER lumen protein retaining receptor 1|ER lumen protein-retaining receptor 1|KDEL endoplasmic reticulum protein retention receptor 1|KDEL receptor 1|putative MAPK-activating protein PM23 |
Swissprots | Q54A39 B2R6N4 Q8NBW7 P24390 |
Accessions | EAW52340 EAW52341 EAW52342 EAW52343 EAW52344 EAW52345 P24390 AB097047 BAC77400 AK075185 BAC11457 AK312647 BAG35531 BC008958 AAH08958 BC018778 AAH18778 DQ891992 ABM82918 DQ895182 ABM86108 X55885 CAA39371 XM_011526358 XP_011524660 NM_006801 NP_006792 |
Function | Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. {ECO:0000269|PubMed:11703931}. |
Subcellular Location | Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:14517323}; Multi-pass membrane protein {ECO:0000269|PubMed:14517323}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14517323}; Multi-pass membrane protein {ECO:0000269|PubMed:14517323}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:14517323}. |
Top Pathways | Vibrio cholerae infection |
KDEL receptor 1 CRISPR/Cas9 KO Plasmid (h) - sc-402751 from Santa Cruz Biotechnology
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KDEL receptor 1 HDR Plasmid (h) - sc-402751-HDR from Santa Cruz Biotechnology
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KDEL receptor 1 Double Nickase Plasmid (h) - sc-402751-NIC from Santa Cruz Biotechnology
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KDEL receptor 1 Double Nickase Plasmid (h2) - sc-402751-NIC-2 from Santa Cruz Biotechnology
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KDEL receptor 1 CRISPR Activation Plasmid (h) - sc-402751-ACT from Santa Cruz Biotechnology
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KDEL receptor 1 CRISPR Activation Plasmid (h2) - sc-402751-ACT-2 from Santa Cruz Biotechnology
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KDEL receptor 1 Lentiviral Activation Particles (h) - sc-402751-LAC from Santa Cruz Biotechnology
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KDEL receptor 1 Lentiviral Activation Particles (h2) - sc-402751-LAC-2 from Santa Cruz Biotechnology
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KDEL receptor 1 siRNA (h) - sc-44736 from Santa Cruz Biotechnology
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KDEL receptor 1 shRNA Plasmid (h) - sc-44736-SH from Santa Cruz Biotechnology
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KDEL receptor 1 shRNA (h) Lentiviral Particles - sc-44736-V from Santa Cruz Biotechnology
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KDELR1 RNAi - H00010945-R02 from Novus Biologicals
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MISSION® esiRNA - EHU000041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11022 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11022 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06019 from Sigma-Aldrich
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KDELR1 siRNA (Human) - CRH7467 from Cohesion Biosciences
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shRNA set against Human KDELR1 (NM_006801.2) - SHH324095 from Creative biogene
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shRNA set against Human KDELR1(NM_006801.2) - SHL193825 from Creative biogene
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Human KDELR1 siRNA - orb267969 from Biorbyt
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KDELR1 shRNA Plasmid (Human) - CHH7467 from Cohesion Biosciences
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KDELR1 miRNA 3'UTR clone - MiUTR1H-05185 from Creative biogene
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