| Gene Symbol |
FERMT3
|
| Entrez Gene |
83706
|
| Alt Symbol |
KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fermitin family member 3
|
| Other Description |
MIG2-like protein|UNC-112 related protein 2|fermitin family homolog 3|kindlin 3|unc-112-related protein 2
|
| Swissprots |
Q9BT48 Q8N207 Q8IUA1 Q86UX7
|
| Accessions |
EAW74199 EAW74200 Q86UX7 AK093719 BAC04220 AL560215 AY093951 AAM19736 AY093952 AAM19737 BC004347 AAH04347 BC013366 AAH13366 BC015584 AAH15584 BG491422 L25343 XM_011545294 XP_011543596 XM_011545295 XP_011543597 XM_011545296 XP_011543598 NM_031471 NP_113659 NM_178443 NP_848537
|
| Function |
Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell projection, podosome {ECO:0000250}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies. {ECO:0000269|PubMed:12697302, ECO:0000269|PubMed:12886250}.
|
![Western Blot: URP2 Overexpression Lysate (Adult Normal) [NBL1-10678] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for URP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6706_URP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10678-img0002.jpg)