Gene Symbol | FERMT3 |
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Entrez Gene | 83706 |
Alt Symbol | KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF |
Species | Human |
Gene Type | protein-coding |
Description | fermitin family member 3 |
Other Description | MIG2-like protein|UNC-112 related protein 2|fermitin family homolog 3|kindlin 3|unc-112-related protein 2 |
Swissprots | Q9BT48 Q8N207 Q8IUA1 Q86UX7 |
Accessions | EAW74199 EAW74200 Q86UX7 AK093719 BAC04220 AL560215 AY093951 AAM19736 AY093952 AAM19737 BC004347 AAH04347 BC013366 AAH13366 BC015584 AAH15584 BG491422 L25343 XM_011545294 XP_011543596 XM_011545295 XP_011543597 XM_011545296 XP_011543598 NM_031471 NP_113659 NM_178443 NP_848537 |
Function | Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250}. |
Subcellular Location | Cell projection, podosome {ECO:0000250}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. {ECO:0000250}. |
Tissue Specificity | Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies. {ECO:0000269|PubMed:12697302, ECO:0000269|PubMed:12886250}. |
Human URP2 full length protein - ab112425 from Abcam
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Human URP2 peptide - ab74769 from Abcam
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URP2 / FERMT3 Antibody Blocking Peptide - LS-E27133 from LifeSpan Bioscience
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URP2 / FERMT3 Antibody Blocking Peptide - LS-E30570 from LifeSpan Bioscience
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Recombinant Human FERMT3/URP2 Protein - H00083706-P01 from Novus Biologicals
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FERMT3/URP2 Blocking Peptide - NBP1-76349PEP from Novus Biologicals
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URP2 Peptide - GTX85027-PEP from GeneTex
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URP2 blocking peptide - GTX88332-PEP from GeneTex
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URP2 Peptide - AC21-1952-P from Abcore
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FERMT3 - H00083706-P01-10 from Acris Antibodies
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FERMT3 - H00083706-P01-25 from Acris Antibodies
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FERMT3 Control Peptide - AP30481CP-N from Acris Antibodies
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FERMT3 Peptide - 42-111P from ProSci
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KINDLIN3 Peptide - 4797P from ProSci
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FERMT3 fusion protein - Ag12713 from Proteintech Group
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Recombinant Human FERMT3, His-tagged - FERMT3-12846H from Creative Biomart
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Recombinant Human Fermitin family homolog 3(FERMT3) - CSB-YP771441HU CSB-EP771441HU CSB-BP771441HU CSB-MP771441HU from Cusabio
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FERMT3 Protein - abx164079 from Abbexa
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FERMT3 (transcript variant URP2SF) - TP302580 from Acris Antibodies
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URP2/kindlin-3, Peptide - MBS426720 from MyBioSource
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FERMT3 Peptide, Human - M34GP05676H from Creative Peptides
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Fermitin family homolog 3 (FERMT3), Recombinant Protein - MBS1352843 from MyBioSource
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FERMT3/URP2 Recombinant Protein Antigen - NBP2-57110PEP from Novus Biologicals
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