| Gene Symbol | COPS8 |
|---|---|
| Entrez Gene | 10920 |
| Alt Symbol | COP9, CSN8, SGN8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | COP9 signalosome subunit 8 |
| Other Description | COP9 constitutive photomorphogenic homolog subunit 8|COP9 homolog|COP9 signalosome complex subunit 8|JAB1-containing signalosome subunit 8|hCOP9|signalosome subunit 8 |
| Swissprots | Q53QS9 A8K1H6 Q99627 |
| Accessions | AAY14978 EAW71097 EAW71098 EAW71099 EAW71100 Q99627 AA004869 AI077560 AI690743 AK289891 BAF82580 AK294078 BAG57420 AK308962 AK313437 BAG36228 AL038738 BC003090 AAH03090 BC036499 AAH36499 BC080617 AAH80617 BF979628 BG721393 BQ716842 CR456994 CAG33275 HQ448684 ADQ33162 U51205 AAB38529 NM_006710 NP_006701 NM_198189 NP_937832 |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}. |