COPS8

Gene Symbol COPS8
Entrez Gene 10920
Alt Symbol COP9, CSN8, SGN8
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 8
Other Description COP9 constitutive photomorphogenic homolog subunit 8|COP9 homolog|COP9 signalosome complex subunit 8|JAB1-containing signalosome subunit 8|hCOP9|signalosome subunit 8
Swissprots Q53QS9 A8K1H6 Q99627
Accessions AAY14978 EAW71097 EAW71098 EAW71099 EAW71100 Q99627 AA004869 AI077560 AI690743 AK289891 BAF82580 AK294078 BAG57420 AK308962 AK313437 BAG36228 AL038738 BC003090 AAH03090 BC036499 AAH36499 BC080617 AAH80617 BF979628 BG721393 BQ716842 CR456994 CAG33275 HQ448684 ADQ33162 U51205 AAB38529 NM_006710 NP_006701 NM_198189 NP_937832
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.

CSN8 CRISPR/Cas9 KO Plasmid (h) - sc-409800 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN8 HDR Plasmid (h) - sc-409800-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN8 Double Nickase Plasmid (h) - sc-409800-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN8 Double Nickase Plasmid (h2) - sc-409800-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN8 CRISPR Activation Plasmid (h) - sc-409800-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN8 CRISPR Activation Plasmid (h2) - sc-409800-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN8 Lentiviral Activation Particles (h) - sc-409800-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN8 Lentiviral Activation Particles (h2) - sc-409800-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN8 siRNA (h) - sc-60467 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN8 shRNA Plasmid (h) - sc-60467-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN8 shRNA (h) Lentiviral Particles - sc-60467-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COPS8 RNAi - H00010920-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU111361 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6439 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6439 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08386 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08386

COPS8 siRNA (Human) - CRH7447 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS8 RNAi - H00010920-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

COPS8 - MBS8206138 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COPS8 (NM_006710.4) - SHH267877 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human COPS8(NM_198189.2) - SHG192907 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human COPS8(NM_006710.4) - SHG192943 from Creative biogene

Category siRNA
Species Reactivities Human

Human COPS8 siRNA - orb267949 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS8 shRNA Plasmid (Human) - CHH7447 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COPS8 miRNA 3'UTR clone - MiUTR1H-02362 from Creative biogene

Species Reactivities Human
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