| Gene Symbol | Alox15 |
|---|---|
| Entrez Gene | 11687 |
| Alt Symbol | 12-LO, 12/15-LO, 15-LOX, Alox12l, L-12LO |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | arachidonate 15-lipoxygenase |
| Other Description | 12-LOX|12/15-lipoxygenase|arachidonate 12-lipoxygenase, leukocyte-type|arachidonate omega-6 lipoxygenase |
| Swissprots | Q4FJY9 P39654 Q5F2E3 Q6PHB2 |
| Accessions | ABV02575 EDL12554 P39654 AK142371 BAE25045 BC056625 AAH56625 BC081546 AAH81546 CT010263 CAJ18471 L34570 AAA64930 U04331 AAA20658 XM_006532036 XP_006532099 XM_006537114 XP_006537177 NM_009660 NP_033790 |
| Function | Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12- hydroperoxyeicosatetraenoic acid/12-HPETE and 15- hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function throug |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:11278875}. Cell membrane {ECO:0000269|PubMed:11278875}; Peripheral membrane protein {ECO:0000269|PubMed:11278875}. Lipid droplet {ECO:0000250}. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells. |
| Tissue Specificity | Found in pituitary and pineal glands as well as leukocytes, kidney, aorta, small intestine and cornea. Also expressed by resident peritoneal macrophages (at protein level). {ECO:0000269|PubMed:15708862, ECO:0000269|PubMed:22503541, ECO:0000269|PubMed:8188678, ECO:0000269|PubMed:8798642}. |
| Top Pathways | Arachidonic acid metabolism, Linoleic acid metabolism |