| Gene Symbol | CHRNA4 |
|---|---|
| Entrez Gene | 1137 |
| Alt Symbol | BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
| Other Description | cholinergic receptor, nicotinic, alpha polypeptide 4|neuronal acetylcholine receptor subunit alpha-4|neuronal nicotinic acetylcholine receptor alpha-4 subunit |
| Swissprots | Q4VAQ5 Q4JGR7 P43681 Q4VAQ6 |
| Accessions | AAV66461 AAW81038 AAW81039 AAY88737 EAW75269 EAW75270 P43681 AK296430 BAG59090 AK314907 BC096290 AAH96290 BC096291 AAH96291 BC096292 AAH96292 BC096293 AAH96293 BM710937 DA530118 L35901 AAA64743 U62433 AAB40111 X87629 CAA60959 X89741 CAA61893 X89742 X89743 X89744 X89745 X89746 Y08421 CAA69698 XM_011528524 XP_011526826 NM_000744 NP_000735 NM_001256573 NP_001243502 NR_046317 |
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. {ECO:0000269|PubMed:22361591}. |
| Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. |
| Top Pathways | Nicotine addiction, Neuroactive ligand-receptor interaction |